Literature DB >> 24394756

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility.

Hywel D Williams1, Yasemin Sahbaz, Leigh Ford, Tri-Hung Nguyen, Peter J Scammells, Christopher J H Porter.   

Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

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Year:  2014        PMID： 24394756     DOI： 10.1039/c3cc48650h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Oral Drug Delivery Technologies-A Decade of Developments.

Authors:  G Kaur; M Arora; M N V Ravi Kumar
Journal:  J Pharmacol Exp Ther       Date:  2019-04-22       Impact factor: 4.030

2.  Ionic liquids for oral insulin delivery.

Authors:  Amrita Banerjee; Kelly Ibsen; Tyler Brown; Renwei Chen; Christian Agatemor; Samir Mitragotri
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-25       Impact factor: 11.205

3.  A New Compartmentalized Scale (PN) for Measuring Polarity Applied to Novel Ether-Functionalized Amino Acid Ionic Liquids.

Authors:  Xu Zheng; Chun Guo; Wenqing Wu; Jing Tong
Journal:  Molecules       Date:  2022-05-18       Impact factor: 4.927

4.  Cytotoxic Activity of Salicylic Acid-Containing Drug Models with Ionic and Covalent Binding.

Authors:  Ksenia S Egorova; Marina M Seitkalieva; Alexandra V Posvyatenko; Victor N Khrustalev; Valentine P Ananikov
Journal:  ACS Med Chem Lett       Date:  2015-09-28       Impact factor: 4.345

5.  Solubility and Stability of Some Pharmaceuticals in Natural Deep Eutectic Solvents-Based Formulations.

Authors:  Natali Rianika Mustafa; Vincent Simon Spelbos; Geert-Jan Witkamp; Robert Verpoorte; Young Hae Choi
Journal:  Molecules       Date:  2021-04-30       Impact factor: 4.411

6.  Wide-Antimicrobial Spectrum of Picolinium Salts.

Authors:  Sarka Salajkova; Marketa Benkova; Jan Marek; Radek Sleha; Lukas Prchal; David Malinak; Rafael Dolezal; Kristina Sepčić; Nina Gunde-Cimerman; Kamil Kuca; Ondrej Soukup
Journal:  Molecules       Date:  2020-05-11       Impact factor: 4.411

7.  Versatile Method for the Simultaneous Synthesis of Two Ionic Liquids, Otherwise Difficult to Obtain, with High Atom Economy.

Authors:  Andrea Szpecht; Adrian Zajac; Dawid Zielinski; Hieronim Maciejewski; Marcin Smiglak
Journal:  ChemistryOpen       Date:  2019-07-18       Impact factor: 2.911

8.  Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure.

Authors:  Erin Tay; Tri-Hung Nguyen; Leigh Ford; Hywel D Williams; Hassan Benameur; Peter J Scammells; Christopher J H Porter
Journal:  Pharmaceutics       Date:  2019-12-22       Impact factor: 6.321

Review 9.  Applications and mechanisms of ionic liquids in whole-cell biotransformation.

Authors:  Lin-Lin Fan; Hong-Ji Li; Qi-He Chen
Journal:  Int J Mol Sci       Date:  2014-07-09       Impact factor: 5.923

Review 10.  Ionic liquids for addressing unmet needs in healthcare.

Authors:  Christian Agatemor; Kelly N Ibsen; Eden E L Tanner; Samir Mitragotri
Journal:  Bioeng Transl Med       Date:  2018-01-19
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