Literature DB >> 24394582

Targeting a c-MYC G-quadruplex DNA with a fragment library.

Hamid R Nasiri1, Neil M Bell, Keith I E McLuckie, Jarmila Husby, Chris Abell, Stephen Neidle, Shankar Balasubramanian.   

Abstract

We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.

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Year:  2014        PMID： 24394582     DOI： 10.1039/c3cc48390h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  A rapid fluorescent indicator displacement assay and principal component/cluster data analysis for determination of ligand-nucleic acid structural selectivity.

Authors:  Rafael Del Villar-Guerra; Robert D Gray; John O Trent; Jonathan B Chaires
Journal:  Nucleic Acids Res       Date:  2018-04-20       Impact factor: 16.971

2.  Platinum(ii) complexes with rutaecarpine and tryptanthrin derivatives induce apoptosis by inhibiting telomerase activity and disrupting mitochondrial function.

Authors:  Qi-Pin Qin; Bi-Qun Zou; Fei-Long Hu; Guo-Bao Huang; Shu-Long Wang; Yun-Qiong Gu; Ming-Xiong Tan
Journal:  Medchemcomm       Date:  2018-08-08       Impact factor: 3.597

Review 3.  Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics.

Authors:  Bing-Jia Chen; Yan-Ling Wu; Yoshimasa Tanaka; Wen Zhang
Journal:  Int J Biol Sci       Date:  2014-09-13       Impact factor: 6.580

4.  Flexibility and structural conservation in a c-KIT G-quadruplex.

Authors:  Dengguo Wei; Jarmila Husby; Stephen Neidle
Journal:  Nucleic Acids Res       Date:  2014-12-01       Impact factor: 16.971

5.  Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression.

Authors:  Kenneth M Felsenstein; Lindsey B Saunders; John K Simmons; Elena Leon; David R Calabrese; Shuling Zhang; Aleksandra Michalowski; Peter Gareiss; Beverly A Mock; John S Schneekloth
Journal:  ACS Chem Biol       Date:  2015-11-06       Impact factor: 5.100

6.  Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin.

Authors:  Arpita Tawani; Subodh Kumar Mishra; Amit Kumar
Journal:  Sci Rep       Date:  2017-06-15       Impact factor: 4.379

7.  Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives as c-Myc G-Quadruplex Binders with Anticancer Activity.

Authors:  Vijaykumar D Nimbarte; Julia Wirmer-Bartoschek; Santosh L Gande; Islam Alshamleh; Marcel Seibert; Hamid Reza Nasiri; Frank Schnütgen; Hubert Serve; Harald Schwalbe
Journal:  ChemMedChem       Date:  2021-03-22       Impact factor: 3.466

8.  A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of c-MYC G-quadruplex and Down-regulates c-MYC Transcription in Human Cancer Cells.

Authors:  Deepanjan Panda; Manish Debnath; Samir Mandal; Irene Bessi; Harald Schwalbe; Jyotirmayee Dash
Journal:  Sci Rep       Date:  2015-08-19       Impact factor: 4.379

9.  Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo.

Authors:  Zeng Li; Chen Liu; Cheng Huang; Xiaoming Meng; Lei Zhang; Jinhui He; Jun Li
Journal:  Oncotarget       Date:  2016-06-07

Review 10.  Current perspectives in fragment-based lead discovery (FBLD).

Authors:  Bas Lamoree; Roderick E Hubbard
Journal:  Essays Biochem       Date:  2017-11-08       Impact factor: 8.000
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