Literature DB >> 24393784

Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.

Fumihiko Urano1.   

Abstract

Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.

Entities:  

Mesh：

Year:  2014        PMID： 24393784      PMCID： PMC4049517          DOI： 10.1038/nrendo.2013.261

Source DB:  PubMed          Journal:  Nat Rev Endocrinol        ISSN： 1759-5029            Impact factor:   43.330


  10 in total

Review 1.  Endoplasmic reticulum stress and pancreatic β-cell death.

Authors:  Sonya G Fonseca; Jesper Gromada; Fumihiko Urano
Journal:  Trends Endocrinol Metab       Date:  2011-03-31       Impact factor: 12.015

2.  WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.

Authors:  Sonya G Fonseca; Mariko Fukuma; Kathryn L Lipson; Linh X Nguyen; Jenny R Allen; Yoshitomo Oka; Fumihiko Urano
Journal:  J Biol Chem       Date:  2005-09-29       Impact factor: 5.157

3.  Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.

Authors:  Sonya G Fonseca; Shinsuke Ishigaki; Christine M Oslowski; Simin Lu; Kathryn L Lipson; Rajarshi Ghosh; Emiko Hayashi; Hisamitsu Ishihara; Yoshitomo Oka; M Alan Permutt; Fumihiko Urano
Journal:  J Clin Invest       Date:  2010-02-15       Impact factor: 14.808

4.  Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.

Authors:  Sonya G Fonseca; Fumihiko Urano; Gordon C Weir; Jesper Gromada; Mark Burcin
Journal:  Nat Cell Biol       Date:  2012-09-16       Impact factor: 28.824

5.  Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Authors:  Feyza Engin; Alena Yermalovich; Truc Nguyen; Truc Ngyuen; Sarah Hummasti; Wenxian Fu; Decio L Eizirik; Diane Mathis; Gökhan S Hotamisligil
Journal:  Sci Transl Med       Date:  2013-11-13       Impact factor: 17.956

6.  Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome.

Authors:  T G Barrett; S E Bundey; A F Macleod
Journal:  Lancet       Date:  1995-12-02       Impact factor: 79.321

Review 7.  The impact of the unfolded protein response on human disease.

Authors:  Shiyu Wang; Randal J Kaufman
Journal:  J Cell Biol       Date:  2012-06-25       Impact factor: 10.539

8.  Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation.

Authors:  Lori L Bonnycastle; Peter S Chines; Takashi Hara; Jeroen R Huyghe; Amy J Swift; Pirkko Heikinheimo; Jana Mahadevan; Sirkku Peltonen; Hanna Huopio; Pirjo Nuutila; Narisu Narisu; Rachel L Goldfeder; Michael L Stitzel; Simin Lu; Michael Boehnke; Fumihiko Urano; Francis S Collins; Markku Laakso
Journal:  Diabetes       Date:  2013-07-31       Impact factor: 9.461

9.  Common variants in WFS1 confer risk of type 2 diabetes.

Authors:  Manjinder S Sandhu; Michael N Weedon; Katherine A Fawcett; Jon Wasson; Sally L Debenham; Allan Daly; Hana Lango; Timothy M Frayling; Rosalind J Neumann; Richard Sherva; Ilana Blech; Paul D Pharoah; Colin N A Palmer; Charlotte Kimber; Roger Tavendale; Andrew D Morris; Mark I McCarthy; Mark Walker; Graham Hitman; Benjamin Glaser; M Alan Permutt; Andrew T Hattersley; Nicholas J Wareham; Inês Barroso
Journal:  Nat Genet       Date:  2007-07-01       Impact factor: 38.330

10.  β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.

Authors:  Linshan Shang; Haiqing Hua; Kylie Foo; Hector Martinez; Kazuhisa Watanabe; Matthew Zimmer; David J Kahler; Matthew Freeby; Wendy Chung; Charles LeDuc; Robin Goland; Rudolph L Leibel; Dieter Egli
Journal:  Diabetes       Date:  2013-11-13       Impact factor: 9.461
  10 in total
  7 in total

1.  IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.

Authors:  Kohsuke Kanekura; Xiucui Ma; John T Murphy; Lihua J Zhu; Abhinav Diwan; Fumihiko Urano
Journal:  Sci Signal       Date:  2015-06-23       Impact factor: 8.192

2.  A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.

Authors:  Simin Lu; Kohsuke Kanekura; Takashi Hara; Jana Mahadevan; Larry D Spears; Christine M Oslowski; Rita Martinez; Mayu Yamazaki-Inoue; Masashi Toyoda; Amber Neilson; Patrick Blanner; Cris M Brown; Clay F Semenkovich; Bess A Marshall; Tamara Hershey; Akihiro Umezawa; Peter A Greer; Fumihiko Urano
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-24       Impact factor: 11.205

3.  Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.

Authors:  Stephen Stone; Damien Abreu; Jana Mahadevan; Rie Asada; Kelly Kries; Rolf Graf; Bess A Marshall; Tamara Hershey; Fumihiko Urano
Journal:  Sci Rep       Date:  2019-03-26       Impact factor: 4.379

4.  A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome.

Authors:  Jana Mahadevan; Shuntaro Morikawa; Takuya Yagi; Damien Abreu; Simin Lu; Kohsuke Kanekura; Cris M Brown; Fumihiko Urano
Journal:  Lab Invest       Date:  2020-05-04       Impact factor: 5.662

Review 5.  Wolfram Syndrome: Diagnosis, Management, and Treatment.

Authors:  Fumihiko Urano
Journal:  Curr Diab Rep       Date:  2016-01       Impact factor: 4.810

6.  Adrenomedullin and its receptors are expressed in mouse pancreatic β-cells and suppresses insulin synthesis and secretion.

Authors:  Yuanlin Dong; Simone Hernandez Ruano; Akansha Mishra; Kathleen A Pennington; Chandrasekhar Yallampalli
Journal:  PLoS One       Date:  2022-03-24       Impact factor: 3.752

7.  Monogenic and syndromic diabetes due to endoplasmic reticulum stress.

Authors:  Stephen I Stone; Damien Abreu; Janet B McGill; Fumihiko Urano
Journal:  J Diabetes Complications       Date:  2020-05-08       Impact factor: 2.852
  7 in total

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