| Literature DB >> 24393764 |
Qishan Zheng1, Tianran Lin1, Hanyin Wu1, Liangqia Guo2, Peirong Ye1, Yanli Hao1, Qingquan Guo1, Jinzhi Jiang1, Fengfu Fu3, Guonan Chen1.
Abstract
A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers. MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N₂ adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media.Entities:
Keywords: Controlled release; Drug delivery; Mesoporous silica nanoparticles; Polydopamine
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Year: 2014 PMID： 24393764 DOI： 10.1016/j.ijpharm.2013.12.045
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875