Bengt Zöller1, Olle Melander2, Peter Svensson3, Gunnar Engström2. 1. Center for Primary Care Research, Lund University/Region Skåne, Malmö, Sweden. Electronic address: bengt.zoller@med.lu.se. 2. Department of Clinical Sciences, Lund University, Clinical Research Center (CRC), Entrance 72, house 60, level 13, Skåne University Hospital, SE 205 02 Malmö, Sweden. 3. Department of Clinical Sciences, Lund University, Clinical Research Center (CRC), Entrance 72, house 60, level 13, Skåne University Hospital, SE 205 02 Malmö, Sweden; Department of Coagulation Disorders, Skåne University Hospital, Malmö, Sweden.
Abstract
INTRODUCTION: Red cell distribution width (RDW) has been associated with venous thromboembolism (VTE), but whether RDW is a predictor of first event of VTE is unknown. We investigated the association between RDW and incidence of first event of VTE in a population-based cohort. MATERIALS AND METHODS: RDW was measured in 27 042 subjects (aged 45-73 years, 60.6% women), without previous history of VTE or cancer within 5 years before follow-up, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of VTE was identified from the patient register and the cause of death register during a mean follow-up of 13.8 years and studied in relation to RDW. RESULTS: During follow-up, 991 subjects (57.5% women) were affected by VTE (pulmonary embolism or deep venous thrombosis of the lower limbs). After adjustment for potential confounding factors the hazard ratios (HR) for VTE for the second, third and fourth RDW quartiles 1.15 (95% confidence interval 0.94-1.41), 1.41 (1.14-1.73), 1.74 (1.38-2.21), respectively, were compared with the bottom quartile of RDW. In the multivariate model subjects with the top 5% of RDW values compared with the bottom quartile had an even higher risk (HR=2.51, 1.78-2.54). In receiver operating characteristic (ROC) analysis, the male specific area under the ROC curve (AUC) for RDW was 0.57 (95% CI 0.54-0.59). The female specific AUC was 0.56 (95% CI 0.53-0.58). CONCLUSIONS: RDW was found to be associated with long-term incidence of first event of VTE among middle-aged subjects.
INTRODUCTION: Red cell distribution width (RDW) has been associated with venous thromboembolism (VTE), but whether RDW is a predictor of first event of VTE is unknown. We investigated the association between RDW and incidence of first event of VTE in a population-based cohort. MATERIALS AND METHODS: RDW was measured in 27 042 subjects (aged 45-73 years, 60.6% women), without previous history of VTE or cancer within 5 years before follow-up, who participated in the Malmö Diet and Cancer study during 1991-1996. Incidence of VTE was identified from the patient register and the cause of death register during a mean follow-up of 13.8 years and studied in relation to RDW. RESULTS: During follow-up, 991 subjects (57.5% women) were affected by VTE (pulmonary embolism or deep venous thrombosis of the lower limbs). After adjustment for potential confounding factors the hazard ratios (HR) for VTE for the second, third and fourth RDW quartiles 1.15 (95% confidence interval 0.94-1.41), 1.41 (1.14-1.73), 1.74 (1.38-2.21), respectively, were compared with the bottom quartile of RDW. In the multivariate model subjects with the top 5% of RDW values compared with the bottom quartile had an even higher risk (HR=2.51, 1.78-2.54). In receiver operating characteristic (ROC) analysis, the male specific area under the ROC curve (AUC) for RDW was 0.57 (95% CI 0.54-0.59). The female specific AUC was 0.56 (95% CI 0.53-0.58). CONCLUSIONS: RDW was found to be associated with long-term incidence of first event of VTE among middle-aged subjects.
Authors: James E Siegler; Christy Marcaccio; Kelsey Nawalinski; Francis Quattrone; Danielle K Sandsmark; Eileen Maloney-Wilensky; Suzanne Frangos; Joshua M Levine; Sherman C Stein; Scott E Kasner; Monisha A Kumar Journal: Neurocrit Care Date: 2017-02 Impact factor: 3.210
Authors: C Chugh; S C Nyirjesy; K P Nawalinski; D K Sandsmark; S Frangos; E Maloney-Wilensky; S C Stein; J M Levine; S E Kasner; M A Kumar Journal: Neurocrit Care Date: 2015-10 Impact factor: 3.210
Authors: Julia Riedl; Florian Posch; Oliver Königsbrügge; Felix Lötsch; Eva-Maria Reitter; Ernst Eigenbauer; Christine Marosi; Ilse Schwarzinger; Christoph Zielinski; Ingrid Pabinger; Cihan Ay Journal: PLoS One Date: 2014-10-27 Impact factor: 3.240