Sara E Murray1, Ricardo V Lloyd2, Rebecca S Sippel1, Herbert Chen1, Sarah C Oltmann3. 1. Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, K4/739 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA. 2. Department of Pathology and Laboratory Medicine, University of Wisconsin, K4/739 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA. 3. Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, K4/739 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: oltmann@surgery.wisc.edu.
Abstract
BACKGROUND: The necessity and frequency of postoperative surveillance for appendiceal carcinoid tumors ≤1 cm are undetermined. METHODS: A retrospective review was conducted of all patients with appendiceal carcinoid tumors ≤1 cm managed at an academic, tertiary referral center. Clinicopathologic characteristics, treatment, surveillance, recurrence, and survival were assessed and analyzed. RESULTS: Over a 16-year period, 31 patients met the inclusion criteria. Appendicitis (n = 17) and pelvic mass (n = 5) were the most common presentations. Median tumor diameter was 5 mm (range, 1-10 mm). Two patients had mesoappendiceal involvement. No patients had regional lymph node involvement or distant metastasis. Postoperatively, 14 patients (45%) received follow-up recommendations, including ≥1 of the following: imaging (n = 9), medical oncology referral (n = 7), colonoscopy (n = 5), and laboratory studies (n = 5). There were no recurrences or disease-specific deaths during a median follow-up period of 5 years (range, 0-15 years). CONCLUSIONS: Appendiceal carcinoids ≤1 cm are unlikely to recur. Therefore, postoperative surveillance may be unnecessary.
BACKGROUND: The necessity and frequency of postoperative surveillance for appendiceal carcinoid tumors ≤1 cm are undetermined. METHODS: A retrospective review was conducted of all patients with appendiceal carcinoid tumors ≤1 cm managed at an academic, tertiary referral center. Clinicopathologic characteristics, treatment, surveillance, recurrence, and survival were assessed and analyzed. RESULTS: Over a 16-year period, 31 patients met the inclusion criteria. Appendicitis (n = 17) and pelvic mass (n = 5) were the most common presentations. Median tumor diameter was 5 mm (range, 1-10 mm). Two patients had mesoappendiceal involvement. No patients had regional lymph node involvement or distant metastasis. Postoperatively, 14 patients (45%) received follow-up recommendations, including ≥1 of the following: imaging (n = 9), medical oncology referral (n = 7), colonoscopy (n = 5), and laboratory studies (n = 5). There were no recurrences or disease-specific deaths during a median follow-up period of 5 years (range, 0-15 years). CONCLUSIONS:Appendiceal carcinoids ≤1 cm are unlikely to recur. Therefore, postoperative surveillance may be unnecessary.
Authors: J Philip Boudreaux; David S Klimstra; Manal M Hassan; Eugene A Woltering; Robert T Jensen; Stanley J Goldsmith; Charles Nutting; David L Bushnell; Martyn E Caplin; James C Yao Journal: Pancreas Date: 2010-08 Impact factor: 3.327
Authors: Shayna Brathwaite; Jonathan Rock; Martha M Yearsley; Tanios Bekaii-Saab; Lai Wei; Wendy L Frankel; John Hays; Christina Wu; Sherif Abdel-Misih Journal: Ann Surg Oncol Date: 2016-03-10 Impact factor: 5.344