Literature DB >> 24392742

4-Quinolone alkaloids from Melochia odorata.

Raquel C Jadulco1, Christopher D Pond, Ryan M Van Wagoner, Michael Koch, Osia G Gideon, Teatulohi K Matainaho, Pius Piskaut, Louis R Barrows.   

Abstract

The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 μM, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.

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Year:  2014        PMID： 24392742      PMCID： PMC3931125          DOI： 10.1021/np400847t

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  21 in total

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4.  Assessment of a cytoprotection assay for the discovery and evaluation of anti-human immunodeficiency virus compounds utilizing a genetically-impaired virus.

Authors:  R Kiser; S Makovsky; S J Terpening; N Laing; D J Clanton
Journal:  J Virol Methods       Date:  1996-04-26       Impact factor: 2.014

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7.  Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.

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8.  Chemotaxonomy of the tribe Antidesmeae (Euphorbiaceae): antidesmone and related compounds.

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9.  The antiviral effect of zidovudine and ribavirin in clinical trials and the use of p24 antigen levels as a virologic marker.

Authors:  S A Spector; C Kennedy; J A McCutchan; S A Bozzette; R G Straube; J D Connor; D D Richman
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Authors:  M K Howett; E B Neely; N D Christensen; B Wigdahl; F C Krebs; D Malamud; S D Patrick; M D Pickel; P A Welsh; C A Reed; M G Ward; L R Budgeon; J W Kreider
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Journal:  Org Lett       Date:  2017-11-17       Impact factor: 6.005

Review 2.  Biologically active quinoline and quinazoline alkaloids part II.

Authors:  Xiao-Fei Shang; Susan L Morris-Natschke; Guan-Zhou Yang; Ying-Qian Liu; Xiao Guo; Xiao-Shan Xu; Masuo Goto; Jun-Cai Li; Ji-Yu Zhang; Kuo-Hsiung Lee
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4.  Synthesis of first ever 4-quinolone-3-carboxylic acid-appended spirooxindole-pyrrolidine derivatives and their biological applications.

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Journal:  Mol Divers       Date:  2016-09-26       Impact factor: 2.943

5.  Synthesis and X-ray study of dispiro 8-nitroquinolone analogues and their cytotoxic properties against human cervical cancer HeLa cells.

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Journal:  Medchemcomm       Date:  2019-01-22       Impact factor: 3.597

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Journal:  Beilstein J Org Chem       Date:  2019-09-13       Impact factor: 2.883

7.  Hypervalent Iodine(III)-Promoted C3-H Regioselective Halogenation of 4-Quinolones under Mild Conditions.

Authors:  Fang Yang; Xiaoqing Wang; Wenzhuo Zhao; Fei Yu; Zhengsen Yu
Journal:  ACS Omega       Date:  2021-11-29

8.  Cooperative Catalysis for the Highly Diastereo- and Enantioselective [4+3]-Cycloannulation of ortho-Quinone Methides and Carbonyl Ylides.

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Journal:  Angew Chem Int Ed Engl       Date:  2020-01-23       Impact factor: 15.336
  8 in total

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