Prajna K1, Ashok Kumar J2, Srinidhi Rai1, Shobith Kumar Shetty1, Tirthal Rai3, Mohamedi Begum4, Shashikala Md1. 1. Tutor, Department of Biochemistry, A.J. Institute of Medical Sciences , Kuntikana, Mangalore-575004, Karnataka, India . 2. Professor, Department of Biochemistry, A.J. Institute of Medical Sciences , Kuntikana, Mangalore-575004, Karnataka, India . 3. Assistant Professor, Department of Biochemistry, K.S. Hegde Medical Academy , Deralakatte, Mangalore-575018, Karnataka, India . 4. Tutor, Department of Physiology, A.J. Institute of Medical Sciences , Kuntikana, Mangalore-575004, Karnataka, India .
Abstract
INTRODUCTION: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated haemoglobin, serum creatinine and urine microalbumin: in type-2 diabetics without any complications; in type-2 diabetics with nephropathy; and in age and sex matched healthy individual (controls). RESULTS: The study observed an increased level of sialic acid in type-2 diabetics without any complications and type-2 diabetics with nephropathy. Serum sialic acid levels in type-2 diabetics without any complications was 64.44 ± 3.93 mg/dl, in type-2 diabetics with nephropathy was 73.88 ± 4.41 mg/dl, and in controls it was 53.16 ± 3.40 mg/dl. Urine sialic acid levels in type-2 diabetics without any complications was 6.62 ± 0.70 mg/dl, in type-2 diabetics with nephropathy was 8.46 ± 0.97 mg/dl, and in controls it was 4.44 ± 0.62 mg/dl. Correlation of sialic acid levels with glycated haemoglobin and urine microalbumin was statistically significant but with serum creatinine was not statistically significant. CONCLUSION: Sialic acid is an important component of vascular cell membrane. Their increased levels indicate extensive vascular damage in type-2 DM. Therefore, estimation of sialic acid levels help in early prediction and prevention of microvascular complications occurring due to diabetics, thereby decreasing the mortality and morbidity in them.
INTRODUCTION:Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated haemoglobin, serum creatinine and urine microalbumin: in type-2 diabetics without any complications; in type-2 diabetics with nephropathy; and in age and sex matched healthy individual (controls). RESULTS: The study observed an increased level of sialic acid in type-2 diabetics without any complications and type-2 diabetics with nephropathy. Serum sialic acid levels in type-2 diabetics without any complications was 64.44 ± 3.93 mg/dl, in type-2 diabetics with nephropathy was 73.88 ± 4.41 mg/dl, and in controls it was 53.16 ± 3.40 mg/dl. Urine sialic acid levels in type-2 diabetics without any complications was 6.62 ± 0.70 mg/dl, in type-2 diabetics with nephropathy was 8.46 ± 0.97 mg/dl, and in controls it was 4.44 ± 0.62 mg/dl. Correlation of sialic acid levels with glycated haemoglobin and urine microalbumin was statistically significant but with serum creatinine was not statistically significant. CONCLUSION:Sialic acid is an important component of vascular cell membrane. Their increased levels indicate extensive vascular damage in type-2 DM. Therefore, estimation of sialic acid levels help in early prediction and prevention of microvascular complications occurring due to diabetics, thereby decreasing the mortality and morbidity in them.
Authors: C E Mogensen; W F Keane; P H Bennett; G Jerums; H H Parving; P Passa; M W Steffes; G E Striker; G C Viberti Journal: Lancet Date: 1995-10-21 Impact factor: 79.321
Authors: Marta Martin-Lorenzo; Laura Gonzalez-Calero; Angeles Ramos-Barron; Maria D Sanchez-Niño; Carlos Gomez-Alamillo; Juan Manuel García-Segura; Alberto Ortiz; Manuel Arias; Fernando Vivanco; Gloria Alvarez-Llamas Journal: J Mol Med (Berl) Date: 2017-10-04 Impact factor: 4.599