Wei-Qiang Tang1, Shi-Hui Wei2. 1. Department of Ophthalmology, the First Affiliated Hospital of General Hospital of Chinese People's Liberation Army, No.51 Fucheng Road, Beijing 100048, China. 2. General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
Abstract
AIM: To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis. METHODS: The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively. RESULTS: Eight of 128 consecutive patients with optic neuritis resulted from varied causes fulfilled the diagnostic criteria for the primary SS. They presented initially with the signs and symptoms of non-specific optic neuritis, and 5 patients presenting without dryness showed a chronic inflammation of submandibular gland or parotid gland, and lymphocyte infiltration was demonstrated by labial gland biopsy in 2 patients. There were serum positive titers for anti-Sjögren syndrome A (SSA) in 7 patients and anti-Sjögren syndrome B (SSB) in 8 patients. Anti-aquaporin-4 (AQP4) antibody was negative in all the 8 patients. Both glucocorticoids and immunosuppressive agent were administered, and visual acuity elevated in 8 eyes (66.7%), 3 patients (37.5%) recurred in the follow-up. CONCLUSION: Primary SS related optic neuritis is less common and easily misdiagnosed. The conventional therapies for optic neuritis could not control the recurrence.
AIM: To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis. METHODS: The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively. RESULTS: Eight of 128 consecutive patients with optic neuritis resulted from varied causes fulfilled the diagnostic criteria for the primary SS. They presented initially with the signs and symptoms of non-specific optic neuritis, and 5 patients presenting without dryness showed a chronic inflammation of submandibular gland or parotid gland, and lymphocyte infiltration was demonstrated by labial gland biopsy in 2 patients. There were serum positive titers for anti-Sjögren syndrome A (SSA) in 7 patients and anti-Sjögren syndrome B (SSB) in 8 patients. Anti-aquaporin-4 (AQP4) antibody was negative in all the 8 patients. Both glucocorticoids and immunosuppressive agent were administered, and visual acuity elevated in 8 eyes (66.7%), 3 patients (37.5%) recurred in the follow-up. CONCLUSION: Primary SS related optic neuritis is less common and easily misdiagnosed. The conventional therapies for optic neuritis could not control the recurrence.
Authors: C Lafitte; Z Amoura; P Cacoub; P Pradat-Diehl; C Picq; F Salachas; J M Léger; J C Piette; J Y Delattre Journal: J Neurol Date: 2001-07 Impact factor: 4.849