Literature DB >> 2439197

Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells.

N Yamashita, H Hamada, T Tsuruo, E Ogata.   

Abstract

Membrane currents were examined in a drug-sensitive human leukemia cell line (K562) and its multidrug-resistant cell line (K562/ADM) under the whole-cell variation of the patch electrode voltage clamp technique. Most K562 cells showed only the outward current, which was completely suppressed by internal Cs+ ions and 20 mM ethyleneglycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid. In contrast to K562 cells, most K562/ADM cells showed tetrodotoxin-sensitive, voltage-gated Na+ channel current in addition to the outward current. Na+ current was observed in four of 29 K562 cells examined, while it was observed in 29 of 33 K562/ADM cells. Two revertant cell lines (R1-3, R1-5) did not show Na+ current. It was concluded that the amplitude of voltage-gated Na+ current increases in association with multidrug resistance in human leukemia cells.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2439197

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  13 in total

1.  Altered intracellular pH regulation in cells with high levels of P-glycoprotein expression.

Authors:  Gregory Young; Luis Reuss; Guillermo A Altenberg
Journal:  Int J Biochem Mol Biol       Date:  2010-06-03

2.  Patch-clamp profile of ion channels in resting murine B lymphocytes.

Authors:  F V McCann; D C McCarthy; R J Noelle
Journal:  J Membr Biol       Date:  1990-03       Impact factor: 1.843

3.  Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cells.

Authors:  Shilpa Dutta; Osbaldo Lopez Charcas; Samuel Tanner; Frédéric Gradek; Virginie Driffort; Sébastien Roger; Katri Selander; Sadanandan E Velu; Wayne Brouillette
Journal:  Bioorg Med Chem       Date:  2018-04-03       Impact factor: 3.641

4.  Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.

Authors:  M E Laniado; E N Lalani; S P Fraser; J A Grimes; G Bhangal; M B Djamgoz; P D Abel
Journal:  Am J Pathol       Date:  1997-04       Impact factor: 4.307

5.  P-glycoprotein is not a swelling-activated Cl- channel; possible role as a Cl- channel regulator.

Authors:  C G Vanoye; G A Altenberg; L Reuss
Journal:  J Physiol       Date:  1997-07-15       Impact factor: 5.182

6.  Influence of the whole-cell patch-clamp configuration on electrophysiological properties of the voltage-dependent sodium current expressed in MDA-MB-231 breast cancer cells.

Authors:  Sébastien Roger; Pierre Besson; Jean-Yves Le Guennec
Journal:  Eur Biophys J       Date:  2003-10-31       Impact factor: 1.733

7.  Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastastic breast cancer cell line.

Authors:  Sébastien Roger; Jean-Yves Le Guennec; Pierre Besson
Journal:  Br J Pharmacol       Date:  2004-01-26       Impact factor: 8.739

8.  Comparison of ion channels in multidrug-resistant and -sensitive human leukemic cells.

Authors:  S C Lee; C Deutsch; W T Beck
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

Review 9.  Voltage-gated sodium channels and metastatic disease.

Authors:  William J Brackenbury
Journal:  Channels (Austin)       Date:  2012-09-01       Impact factor: 2.581

Review 10.  Voltage-gated sodium channels and cancer: is excitability their primary role?

Authors:  Sébastien Roger; Ludovic Gillet; Jean-Yves Le Guennec; Pierre Besson
Journal:  Front Pharmacol       Date:  2015-07-29       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.