Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 What is the role of autoimmunity in type 1 diabetes? A clinical perspective.

Literature DB >> 24389751

What is the role of autoimmunity in type 1 diabetes? A clinical perspective.

Marc Y Donath¹, Christoph Hess, Ed Palmer.

Abstract

Despite tremendous research efforts, type 1 diabetes is one of the few remaining autoimmune diseases without any approved immunological treatment. This observation compels us to reconsider the role of autoimmunity in the pathogenesis of this disease. In this commentary, we will review solely human data in an attempt to appreciate, in an unbiased manner, the importance and relevance of the immunological alterations in patients with type 1 diabetes. The aim of this paper is to generate reflection on this topic, rather than a controversy.

Entities: Disease Species

Mesh：

Year: 2014 PMID： 24389751 DOI： 10.1007/s00125-013-3153-0

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

23 in total

1. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

Authors: S R Targan; S B Hanauer; S J van Deventer; L Mayer; D H Present; T Braakman; K L DeWoody; T F Schaible; P J Rutgeerts
Journal: N Engl J Med Date: 1997-10-09 Impact factor: 91.245

Review 2. Genetics of type 1A diabetes.

Authors: Patrick Concannon; Stephen S Rich; Gerald T Nepom
Journal: N Engl J Med Date: 2009-04-16 Impact factor: 91.245

Review 3. Biomarkers and immune-modulating therapies for type 2 diabetes.

Authors: Barbara Brooks-Worrell; Radhika Narla; Jerry P Palmer
Journal: Trends Immunol Date: 2012-08-14 Impact factor: 16.687

4. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials.

Authors: Antoinette Moran; Brian Bundy; Dorothy J Becker; Linda A DiMeglio; Stephen E Gitelman; Robin Goland; Carla J Greenbaum; Kevan C Herold; Jennifer B Marks; Philip Raskin; Srinath Sanda; Desmond Schatz; Diane K Wherrett; Darrell M Wilson; Jeffrey P Krischer; Jay S Skyler; Linda Pickersgill; Eelco de Koning; Anette-G Ziegler; Bernhard Böehm; Klaus Badenhoop; Nanette Schloot; Jens Friis Bak; Paolo Pozzilli; Didac Mauricio; Marc Y Donath; Luis Castaño; Ana Wägner; Hans Henrik Lervang; Hans Perrild; Thomas Mandrup-Poulsen
Journal: Lancet Date: 2013-04-05 Impact factor: 79.321

Review 5. Advances in human antiglomerular basement membrane disease.

Authors: Zhao Cui; Ming-Hui Zhao
Journal: Nat Rev Nephrol Date: 2011-07-19 Impact factor: 28.314

6. Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients.

Authors: Volkert A L Huurman; Katelijn Decochez; Chantal Mathieu; Irun R Cohen; Bart O Roep
Journal: Diabetes Metab Res Rev Date: 2007-05 Impact factor: 4.876

7. Beta-cell replication is increased in donor organs from young patients after prolonged life support.

Authors: Peter In't Veld; Neelke De Munck; Kristien Van Belle; Nicole Buelens; Zhidong Ling; Ilse Weets; Patrick Haentjens; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers
Journal: Diabetes Date: 2010-04-22 Impact factor: 9.461

8. Screening for insulitis in adult autoantibody-positive organ donors.

Authors: Peter In't Veld; Dirk Lievens; Joeri De Grijse; Zhidong Ling; Bart Van der Auwera; Miriam Pipeleers-Marichal; Frans Gorus; Daniel Pipeleers
Journal: Diabetes Date: 2007-06-11 Impact factor: 9.461

9. Disappearance and reappearance of islet cell cytoplasmic antibodies in cyclosporin-treated insulin-dependent diabetics.

Authors: T Mandrup-Poulsen; J Nerup; C R Stiller; B Marner; G Bille; D Heinrichs; R Martell; J Dupre; P A Keown; M R Jenner
Journal: Lancet Date: 1985-03-16 Impact factor: 79.321

10. Recurrence of disease in pancreas transplants.

Authors: D E Sutherland; F C Goetz; R K Sibley
Journal: Diabetes Date: 1989-01 Impact factor: 9.461

17 in total

Review 1. The case for an autoimmune aetiology of type 1 diabetes.

Authors: S I Mannering; V Pathiraja; T W H Kay
Journal: Clin Exp Immunol Date: 2015-10-21 Impact factor: 4.330

Review 2. Targeting Innate Immunity for Type 1 Diabetes Prevention.

Authors: James C Needell; Danny Zipris
Journal: Curr Diab Rep Date: 2017-09-27 Impact factor: 4.810

3. Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary? Reply to Campbell-Thompson ML, Atkinson MA, Butler AE et al [letter].

Authors: Marcus Lundberg; Peter Seiron; Sofie Ingvast; Olle Korsgren; Oskar Skog
Journal: Diabetologia Date: 2017-01-22 Impact factor: 10.122

4. Type 1 diabetes as an autoimmune disease: the evidence.

Authors: Stavroula A Paschou; Asimina Petsiou; Katerina Chatzigianni; Agathocles Tsatsoulis; George K Papadopoulos
Journal: Diabetologia Date: 2014-04-06 Impact factor: 10.122

5. Autoantibodies and type 1 diabetes: are we still in the cave of an ancient myth?

Authors: Alfonso Galderisi
Journal: Diabetologia Date: 2014-05-17 Impact factor: 10.122

6. In vivo imaging of type 1 diabetes immunopathology using eye-transplanted islets in NOD mice.

Authors: Midhat H Abdulreda; R Damaris Molano; Gaetano Faleo; Maite Lopez-Cabezas; Alexander Shishido; Ulisse Ulissi; Carmen Fotino; Luis F Hernandez; Ashley Tschiggfrie; Virginia R Aldrich; Alejandro Tamayo-Garcia; Allison S Bayer; Camillo Ricordi; Alejandro Caicedo; Peter Buchwald; Antonello Pileggi; Per-Olof Berggren
Journal: Diabetologia Date: 2019-05-14 Impact factor: 10.122

7. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants.

Authors: Farah A Meah; Linda A DiMeglio; Carla J Greenbaum; Janice S Blum; Jay M Sosenko; Alberto Pugliese; Susan Geyer; Ping Xu; Carmella Evans-Molina
Journal: Diabetologia Date: 2016-03-19 Impact factor: 10.122