| Literature DB >> 24388808 |
Yutaka Aoyagi1, Koji Fujiwara2, Akira Yamazaki2, Naoko Sugawara2, Reiko Yano3, Haruhiko Fukaya2, Yukio Hitotsuyanagi2, Koichi Takeya4, Aki Ishiyama5, Masato Iwatsuki5, Kazuhiko Otoguro5, Haruki Yamada6, Satoshi Ōmura6.
Abstract
A series of analogues of salviandulin E, a rearranged neoclerodane diterpene originally isolated from Salvia leucantha (Lamiaceae), were prepared and their in vitro activity against Trypanosoma brucei brucei was evaluated with currently used therapeutic drugs as positive controls. One of the 19 compounds prepared and assayed in the present study, butanoyl 3,4-dihydrosalviandulin E analogue was found to be a possible candidate for an antitrypanosomal drug with fairly strong antitrypanosomal activity and lower cytotoxicity.Entities:
Keywords: Antitrypanosomal activity; Neoclerodane diterpene; Salvia leucantha; Salviandulin E; Semisynthesis
Mesh：
Substances：
Year: 2013 PMID： 24388808 DOI： 10.1016/j.bmcl.2013.12.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823