Yoshiaki Minakata1, Akihito Sugino2, Masae Kanda3, Tomohiro Ichikawa4, Keiichiro Akamatsu5, Akira Koarai6, Tsunahiko Hirano7, Masanori Nakanishi8, Hisatoshi Sugiura9, Kazuto Matsunaga10, Masakazu Ichinose11. 1. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: minakaty@wakayama-med.ac.jp. 2. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: alternate_hope_and_fear_0806@yahoo.co.jp. 3. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: k97025@yahoo.co.jp. 4. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: 1kawa@wakayama-med.ac.jp. 5. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: akamatsu@wakayama-med.ac.jp. 6. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan. Electronic address: koarai@rm.med.tohoku.ac.jp. 7. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: tsuna@wakayama-med.ac.jp. 8. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: masa-n@wakayama-med.ac.jp. 9. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan. Electronic address: sugiura@rm.med.tohoku.ac.jp. 10. Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: kazmatsu@wakayama-med.ac.jp. 11. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan. Electronic address: ichinose@rm.med.tohoku.ac.jp.
Abstract
BACKGROUND: There is increasing interest in the quantification of physical activity (PA) with an accelerometer for the management of chronic obstructive pulmonary disease (COPD). However, a detailed understanding of the PA in Japanese patients with COPD is lacking. We evaluated the levels of PA in terms of intensity in Japanese patients with COPD and evaluated the factors, which could influence the PA. METHODS: Forty-three outpatients with COPD and 21 age-matched healthy subjects were monitored with a triaxial accelerometer, and their PA was compared. Furthermore, the effects of pulmonary function, ADO index (age, dyspnea, and airflow obstruction) and modified BODE index (body mass index, airflow obstruction, dyspnea, and exercise capacity) on the PA were evaluated. RESULTS: The PA in COPD was significantly reduced at all intensities. The reduced levels of PA in COPD were 23.1% at ≥2.0 metabolic equivalents (METs), 33.0% at ≥2.5 METs, 50.9% at ≥3.0 METs, and 66.9% at ≥3.5 METs, compared with that of healthy subjects, and the reduction was significant at GOLD stage III. The values of FVC, FEV1.0, and DLCO/VA were correlated with that of the PA, but the lung volume parameters were not. The ADO and modified BODE indices were also well correlated with the PA. CONCLUSIONS: The reduced levels of PA in Japanese patients with COPD were objectively demonstrated in terms of intensity that could provide us a new target for the management of COPD.
BACKGROUND: There is increasing interest in the quantification of physical activity (PA) with an accelerometer for the management of chronic obstructive pulmonary disease (COPD). However, a detailed understanding of the PA in Japanese patients with COPD is lacking. We evaluated the levels of PA in terms of intensity in Japanese patients with COPD and evaluated the factors, which could influence the PA. METHODS: Forty-three outpatients with COPD and 21 age-matched healthy subjects were monitored with a triaxial accelerometer, and their PA was compared. Furthermore, the effects of pulmonary function, ADO index (age, dyspnea, and airflow obstruction) and modified BODE index (body mass index, airflow obstruction, dyspnea, and exercise capacity) on the PA were evaluated. RESULTS: The PA in COPD was significantly reduced at all intensities. The reduced levels of PA in COPD were 23.1% at ≥2.0 metabolic equivalents (METs), 33.0% at ≥2.5 METs, 50.9% at ≥3.0 METs, and 66.9% at ≥3.5 METs, compared with that of healthy subjects, and the reduction was significant at GOLD stage III. The values of FVC, FEV1.0, and DLCO/VA were correlated with that of the PA, but the lung volume parameters were not. The ADO and modified BODE indices were also well correlated with the PA. CONCLUSIONS: The reduced levels of PA in Japanese patients with COPD were objectively demonstrated in terms of intensity that could provide us a new target for the management of COPD.
Keywords:
ADO index; Accelerometer; BODE index; COPD; Intensity; METs; MMRC; PA; index including age, dyspnea, and airflow obstruction; index including body-mass index, airflow obstruction, dyspnea, and exercise capacity; metabolic equivalents; modified Medical Research Council; physical activity