| Literature DB >> 24388171 |
Abstract
How TGF-β signaling switches from enforcing pluripotency to promoting mesendodermal differentiation remains an open question. Recently in Cell Reports, Beyer et al. demonstrated that Hippo signaling components recruit the NuRD complex to repress expression of key genes targeted by TGF-β and thus determine whether TGF-β signaling will favor pluripotency or differentiation.Entities:
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Year: 2014 PMID: 24388171 PMCID: PMC3941189 DOI: 10.1016/j.stem.2013.12.009
Source DB: PubMed Journal: Cell Stem Cell ISSN: 1875-9777 Impact factor: 24.633