Erwan Donal1, Lars H Lund2, Emmanuel Oger3, Camilla Hage2, Hans Persson4, Amélie Reynaud5, Pierre-Vladimir Ennezat6, Fabrice Bauer7, Catherine Sportouch-Dukhan8, Elodie Drouet8, Jean-Claude Daubert9, Cecilia Linde2. 1. Département de Cardiologie & CIC-IT U 804, Hôpital Pontchaillou, CHU de Rennes, rue Henri-Le-Guillou, 35000 Rennes, France; LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France. Electronic address: erwan.donal@chu-rennes.fr. 2. Department of Medicine, Karolinska Institutet and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France. 3. Clinical Investigation Center INSERM CIC-0203, CHU de Rennes, Rennes, France; Société française de cardiologie, Paris, France. 4. Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France. 5. LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France. 6. Service de Cardiologie, CHU de Lille, Lille, France; Société française de cardiologie, Paris, France. 7. Département de Cardiologie, CHU de Rouen, Rouen, France; Société française de cardiologie, Paris, France. 8. Département de Cardiologie, CHU de Montpellier, Montpellier, France; Société française de cardiologie, Paris, France. 9. Département de Cardiologie & CIC-IT U 804, Hôpital Pontchaillou, CHU de Rennes, rue Henri-Le-Guillou, 35000 Rennes, France; LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France.
Abstract
BACKGROUND: Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failure patients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity. AIMS: To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up. METHODS: Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)>100 ng/L or N-terminal pro-BNP (NT-proBNP)>300 ng/L and left ventricular ejection fraction (LVEF)>45%. RESULTS: The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P<0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2). CONCLUSIONS: Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709).
BACKGROUND: Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failurepatients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity. AIMS: To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up. METHODS:Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)>100 ng/L or N-terminal pro-BNP (NT-proBNP)>300 ng/L and left ventricular ejection fraction (LVEF)>45%. RESULTS: The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P<0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2). CONCLUSIONS:Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709).
Authors: Marijana Tadic; Elisabeth Pieske-Kraigher; Cesare Cuspidi; Martin Genger; Daniel A Morris; Kun Zhang; Nina Alexandra Walther; Burket Pieske Journal: Heart Fail Rev Date: 2017-05 Impact factor: 4.214
Authors: Olivier Huttin; Alan G Fraser; Lars H Lund; Erwan Donal; Cecilia Linde; Masatake Kobayashi; Tamas Erdei; Jean-Loup Machu; Kevin Duarte; Patrick Rossignol; Walter Paulus; Faiez Zannad; Nicolas Girerd Journal: ESC Heart Fail Date: 2021-03-03
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