| Literature DB >> 24387625 |
Willian J Andrioli1, Raphael Conti, Magali J Araújo, Riccardo Zanasi, Bruno C Cavalcanti, Viviane Manfrim, Juliano S Toledo, Daniele Tedesco, Manoel O de Moraes, Cláudia Pessoa, Angela K Cruz, Carlo Bertucci, José Sabino, Dhammika N P Nanayakkara, Mônica T Pupo, Jairo K Bastos.
Abstract
Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays.Entities:
Mesh：
Substances：
Year: 2014 PMID： 24387625 DOI： 10.1021/np4006822
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050