Literature DB >> 2438687

Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin.

A Müllbacher, D Hume, A W Braithwaite, P Waring, R D Eichner.   

Abstract

The fungal metabolite gliotoxin at low concentrations prevents mitogen stimulation of mature lymphocytes as a result of gliotoxin-induced genomic DNA degradation. Bone marrow, on the other hand, contains a subpopulation of cells resistant to gliotoxin at similar concentrations. This population includes the hemopoietic progenitor cells that grow in vitro in response to appropriate colony-stimulating factors and cells that form colonies in the spleens of lethally irradiated recipients. Gliotoxin treatment of lymph node cell-enriched bone marrow significantly delayed the onset of graft-versus-host disease in fully allogeneic bone marrow chimeras.

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Year:  1987        PMID： 2438687      PMCID： PMC304968          DOI： 10.1073/pnas.84.11.3822

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

Authors:  J E TILL; E A McCULLOCH
Journal:  Radiat Res       Date:  1961-02       Impact factor: 2.841

2.  The effect of T lymphocyte depletion on neonatal tolerance induction, graft-vs.-host disease and cellular chimerism.

Authors:  L S Rayfield; L Brent
Journal:  Eur J Immunol       Date:  1984-04       Impact factor: 5.532

3.  Tolerance, immunocompetence, and secondary disease in fully allogeneic radiation chimeras.

Authors:  L S Rayfield; L Brent
Journal:  Transplantation       Date:  1983-08       Impact factor: 4.939

Review 4.  Allogeneic bone-marrow transplantation.

Authors:  R Storb; E D Thomas
Journal:  Immunol Rev       Date:  1983       Impact factor: 12.988

5.  Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro.

Authors:  A Müllbacher; P Waring; R D Eichner
Journal:  J Gen Microbiol       Date:  1985-05

6.  Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. I. Generation of superoxide radical by sporidesmin.

Authors:  R Munday
Journal:  Chem Biol Interact       Date:  1982-09       Impact factor: 5.192

7.  Bone marrow transplantation across major histocompatibility barriers in mice. Effect of elimination of T cells from donor grafts by treatment with monoclonal Thy-1.2 plus complement or antibody alone.

Authors:  D A Vallera; C C Soderling; G J Carlson; J H Kersey
Journal:  Transplantation       Date:  1981-03       Impact factor: 4.939

8.  Graft rejection and graft-versus-host disease: mirror images.

Authors:  R P Gale; Y Reisner
Journal:  Lancet       Date:  1986-06-28       Impact factor: 79.321

9.  Immunosuppression in vitro by a metabolite of a human pathogenic fungus.

Authors:  A Müllbacher; R D Eichner
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow.

Authors:  R Korngold; J Sprent
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307
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  6 in total

Review 1.  Aspergillus fumigatus and aspergillosis.

Authors:  J P Latgé
Journal:  Clin Microbiol Rev       Date:  1999-04       Impact factor: 26.132

2.  In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi.

Authors:  P Sutton; N R Newcombe; P Waring; A Müllbacher
Journal:  Infect Immun       Date:  1994-04       Impact factor: 3.441

3.  Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

Authors:  D M Vigushin; N Mirsaidi; G Brooke; C Sun; P Pace; L Inman; C J Moody; R C Coombes
Journal:  Med Oncol       Date:  2004       Impact factor: 3.064

4.  Gliotoxin inhibits transformation and its cytotoxic to turkey peripheral blood lymphocytes.

Authors:  J L Richard; W M Peden; P P Williams
Journal:  Mycopathologia       Date:  1994-05       Impact factor: 2.574

5.  The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice.

Authors:  Julian Pardo; Christin Urban; Eva M Galvez; Paul G Ekert; Uwe Müller; June Kwon-Chung; Mario Lobigs; Arno Müllbacher; Reinhard Wallich; Christoph Borner; Markus M Simon
Journal:  J Cell Biol       Date:  2006-08-07       Impact factor: 10.539

6.  Aspergillus fumigatus Inhibits Pseudomonas aeruginosa in Co-culture: Implications of a Mutually Antagonistic Relationship on Virulence and Inflammation in the CF Airway.

Authors:  Emma Reece; Sean Doyle; Peter Greally; Julie Renwick; Siobhán McClean
Journal:  Front Microbiol       Date:  2018-06-05       Impact factor: 5.640
  6 in total

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