Literature DB >> 2438603

Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat.

T Green, G J Dockray.   

Abstract

Combined immunohistochemistry and retrograde tracing was used to investigate the origin of the sensory calcitonin gene-related peptide (CGRP) innervation of the rat stomach. Up to 85% of spinal gastric afferents (T6-L1) contained CGRP immunoreactivity compared with less than 6% of vagal gastric afferents. By comparison substance P immunoreactivity occurred in about 50% of spinal gastric afferents and less than 2% of vagal afferents. The vagal afferents to the oesophagus were 14 and 26% substance P- and CGRP-immunoreactive respectively. The results suggest an important role for CGRP in gastric spinal afferents.

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Year:  1987        PMID: 2438603     DOI: 10.1016/0304-3940(87)90707-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  32 in total

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