Masaru Nemoto1, Katsuyuki Hoshina1, Toshio Takayama2, Sumio Miura3, Tatsu Nakazawa4, Masaaki Kato2, Kunihiro Shigematsu1, Tetsuro Miyata1, Toshiaki Watanabe5. 1. Department of Vascular Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. 2. Department of Cardiovascular Surgery, Morinomiya Hospital, Osaka, Osaka, Japan. 3. Department of Cardiovascular Surgery, Mitsui Memorial Hospital, Tokyo, Japan. 4. Department of Surgery, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan. 5. Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Abstract
OBJECTIVE: Statins have been used widely to reduce dyslipidemia and recently have been reported to have pleiotropic effects such as plaque reduction and stabilization. This study retrospectively evaluated the regression of extensive thoracic atheromas ("shaggy aorta") in abdominal aortic aneurysm (AAA) patients who underwent contrast-enhanced computed tomography (CECT) before and after statin administration. MATERIALS AND METHODS: CECT was used to examine thoracic aortas of 29 patients (statin group; n = 22, non-statin group; n = 7) with extensive atheromas from the ostium of the left subclavian artery to that of the more proximal renal artery. Extensive thoracic atheroma was defined by: (1) thickness >5 mm, (2) involved circumference of thoracic aorta >50%, and (3) length >30 mm. The areas of atheroma (cm(2)) were measured before and after administration of statins, and the atheroma reduction ratio (ARR) was evaluated. RESULTS: The area of atheroma decreased after administration of statins, and the ARR was significant (P <0.01). The ARR increased with all cases in non-statin group. No complications associated with extensive atheroma were observed during the follow-up period. CONCLUSION: This pilot study indicates statins can reduce extensive thoracic atheromas and lower lipid concentrations.
OBJECTIVE: Statins have been used widely to reduce dyslipidemia and recently have been reported to have pleiotropic effects such as plaque reduction and stabilization. This study retrospectively evaluated the regression of extensive thoracic atheromas ("shaggy aorta") in abdominal aortic aneurysm (AAA) patients who underwent contrast-enhanced computed tomography (CECT) before and after statin administration. MATERIALS AND METHODS: CECT was used to examine thoracic aortas of 29 patients (statin group; n = 22, non-statin group; n = 7) with extensive atheromas from the ostium of the left subclavian artery to that of the more proximal renal artery. Extensive thoracic atheroma was defined by: (1) thickness >5 mm, (2) involved circumference of thoracic aorta >50%, and (3) length >30 mm. The areas of atheroma (cm(2)) were measured before and after administration of statins, and the atheroma reduction ratio (ARR) was evaluated. RESULTS: The area of atheroma decreased after administration of statins, and the ARR was significant (P <0.01). The ARR increased with all cases in non-statin group. No complications associated with extensive atheroma were observed during the follow-up period. CONCLUSION: This pilot study indicates statins can reduce extensive thoracic atheromas and lower lipid concentrations.
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