Sinasi Ozsoylu1. 1. Retired Prof of Pediatrics, Hematology, Hepatology, Ankara, Turkey ; Honorary Fellow of American Academy of Pediatrics ; Honorary Member of American Pediatric Society.
To the Editor,The study by Eğin and Akar [1] entitled, First observation of MTHFR 678C-A (Ala 222 Ala) single nucleotide polymorphism, in the recent issue of the Journal (2012; 29: 204-5) requires questioning its importance to thrombosis in the light of Dayal et al.’s findings in a mouse model [2]. I used to think that high homocysteine level important in thrombosis, whereas currently I question such knowledge. As such, I think the authors must show the functional effect of their observation in blood coagulation and its relationship to the thermolabile variant of MTHFR ?.
Authors: Sanjana Dayal; Anil K Chauhan; Melissa Jensen; Lorie Leo; Cynthia M Lynch; Frank M Faraci; Warren D Kruger; Steven R Lentz Journal: Blood Date: 2011-12-20 Impact factor: 22.113