Literature DB >> 24385680

Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams.

Qin Zang1, Salim Javed2, Aihua Zhou1, Chris A Knudtson1, Danse Bi1, Fatima Z Basha3, Paul R Hanson1.   

Abstract

The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several additional cyclization strategies have been realized enabling access to new bicyclic sultams.

Entities:  

Year:  2012        PMID： 24385680      PMCID： PMC3873775          DOI： 10.3987/COM-12-S(N)122

Source DB:  PubMed          Journal:  Heterocycles        ISSN： 0385-5414            Impact factor:   0.831


  14 in total

1.  Drug discovery: a historical perspective.

Authors:  J Drews
Journal:  Science       Date:  2000-03-17       Impact factor: 47.728

2.  Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

Authors:  Nicolas Charrier; Brian Clarke; Emmanuel Demont; Colin Dingwall; Rachel Dunsdon; Julie Hawkins; Julia Hubbard; Ishrut Hussain; Graham Maile; Rosalie Matico; Julie Mosley; Alan Naylor; Alistair O'Brien; Sally Redshaw; Paul Rowland; Virginie Soleil; Kathrine J Smith; Sharon Sweitzer; Pam Theobald; David Vesey; Daryl S Walter; Gareth Wayne
Journal:  Bioorg Med Chem Lett       Date:  2009-04-05       Impact factor: 2.823

Review 3.  Recent developments in the synthesis of fused sultams.

Authors:  K C Majumdar; Shovan Mondal
Journal:  Chem Rev       Date:  2011-09-06       Impact factor: 60.622

Review 4.  Anticancer and antiviral sulfonamides.

Authors:  Andrea Scozzafava; Takashi Owa; Antonio Mastrolorenzo; Claudiu T Supuran
Journal:  Curr Med Chem       Date:  2003-06       Impact factor: 4.530

5.  Route to three-dimensional fragments using diversity-oriented synthesis.

Authors:  Alvin W Hung; Alex Ramek; Yikai Wang; Taner Kaya; J Anthony Wilson; Paul A Clemons; Damian W Young
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

6.  Antiepileptic property of inhibitors of carbonic anhydrase.

Authors:  H Tanimukai; M Inui; S Hariguchi; Z Kaneko
Journal:  Biochem Pharmacol       Date:  1965-06       Impact factor: 5.858

7.  Synthesis of cyclic sulfonamides through intramolecular Diels-Alder reactions.

Authors:  I R Greig; M J Tozer; P T Wright
Journal:  Org Lett       Date:  2001-02-08       Impact factor: 6.005

8.  Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.

Authors:  Cláudia Valente; Rita C Guedes; Rui Moreira; Jim Iley; Jiri Gut; Philip J Rosenthal
Journal:  Bioorg Med Chem Lett       Date:  2006-05-12       Impact factor: 2.823

9.  Chemoselective electrophilic oxidation of heteroatoms by hydroperoxy sultams.

Authors:  Feyissa Gadissa Gelalcha; Bärbel Schulze
Journal:  J Org Chem       Date:  2002-11-29       Impact factor: 4.354

10.  "Click, click, cyclize": a DOS approach to sultams utilizing vinyl sulfonamide linchpins.

Authors:  Aihua Zhou; Dinesh Rayabarapu; Paul R Hanson
Journal:  Org Lett       Date:  2009-02-05       Impact factor: 6.005
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  1 in total

1.  A summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.

Authors:  Ben Niu; Ping Xie; Min Wang; Yanjie Wang; Wannian Zhao; Charles U Pittman; Aihua Zhou
Journal:  Mol Divers       Date:  2015-04-03       Impact factor: 2.943
  1 in total

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