Linda Y Belayev1, Paul M Palevsky. 1. aRenal-Electrolyte Division, University of Pittsburgh School of Medicine bRenal Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Abstract
PURPOSE OF REVIEW: It has been argued that the existing epidemiologic data are insufficient to establish a causal link between acute kidney injury (AKI) and subsequent development or progression of chronic kidney disease (CKD), especially given that risk factors for the development of AKI overlap with those for progressive CKD. RECENT FINDINGS: Multiple studies published over the past 5 years have demonstrated a strong epidemiologic association between episodes of AKI and subsequent development or progression of CKD, including evidence that severity of AKI and repeated episodes of AKI are associated with increased risk of CKD. In addition, animal models have provided evidence for a biological basis linking episodes of AKI with CKD. SUMMARY: The preponderance of data support a causal link between episodes of AKI and subsequent development or progression of CKD.
PURPOSE OF REVIEW: It has been argued that the existing epidemiologic data are insufficient to establish a causal link between acute kidney injury (AKI) and subsequent development or progression of chronic kidney disease (CKD), especially given that risk factors for the development of AKI overlap with those for progressive CKD. RECENT FINDINGS: Multiple studies published over the past 5 years have demonstrated a strong epidemiologic association between episodes of AKI and subsequent development or progression of CKD, including evidence that severity of AKI and repeated episodes of AKI are associated with increased risk of CKD. In addition, animal models have provided evidence for a biological basis linking episodes of AKI with CKD. SUMMARY: The preponderance of data support a causal link between episodes of AKI and subsequent development or progression of CKD.
Authors: F Liaño; C Felipe; M T Tenorio; M Rivera; V Abraira; J M Sáez-de-Urturi; J Ocaña; C Fuentes; S Severiano Journal: Kidney Int Date: 2007-01-31 Impact factor: 10.612
Authors: Arpita Baisantry; Sagar Bhayana; Song Rong; Esther Ermeling; Christoph Wrede; Jan Hegermann; Petra Pennekamp; Inga Sörensen-Zender; Hermann Haller; Anette Melk; Roland Schmitt Journal: J Am Soc Nephrol Date: 2015-10-20 Impact factor: 10.121
Authors: Eric D'hoore; Nathalie Neirynck; Eva Schepers; Raymond Vanholder; Francis Verbeke; Mira Van Thielen; Wim Van Biesen Journal: J Nephrol Date: 2015-02-21 Impact factor: 3.902