Jun Liu1, Yanjun Jia1, Xiaolin Li1, Ruixia Xu1, Chenggang Zhu1, Yuanlin Guo1, Naqiong Wu1, Jianjun Li2. 1. Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. 2. Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. Email: lijianjun938@yahoo.com.
Abstract
BACKGROUND: Several studies investigating the prognostic utility of interleukin-10 (IL-10) in patients with acute coronary syndrome (ACS) have provided conflicting findings. The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events. METHODS: Literature search was performed in PubMed, EMBASE, and Cochrane Trials Register databases from their inception to September 30, 2012. In addition, reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies. RESULTS: A total of 12 eligible studies comprising a total of 5882 patients were identified. The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events. Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable. CONCLUSIONS: Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS. Large study with longer follow-up is needed to confirm the findings.
BACKGROUND: Several studies investigating the prognostic utility of interleukin-10 (IL-10) in patients with acute coronary syndrome (ACS) have provided conflicting findings. The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events. METHODS: Literature search was performed in PubMed, EMBASE, and Cochrane Trials Register databases from their inception to September 30, 2012. In addition, reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies. RESULTS: A total of 12 eligible studies comprising a total of 5882 patients were identified. The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events. Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable. CONCLUSIONS: Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS. Large study with longer follow-up is needed to confirm the findings.
Authors: Elizabeth J Reverri; Colette D LaSalle; Adrian A Franke; Francene M Steinberg Journal: Mol Nutr Food Res Date: 2014-12-05 Impact factor: 5.914
Authors: Cassio Kampits; Marlon M Montenegro; Ingrid W J Ribeiro; Mariana V Furtado; Carisi A Polanczyk; Cassiano K Rösing; Alex N Haas Journal: J Appl Oral Sci Date: 2016 Jul-Aug Impact factor: 2.698
Authors: William C Hedderson; Paul A Borsa; Roger B Fillingim; Stephen A Coombes; Chris J Hass; Steven Z George Journal: Clin J Pain Date: 2020-10 Impact factor: 3.423
Authors: Gisela A Kristono; Ana S Holley; Prashant Lakshman; Morgane M Brunton-O'Sullivan; Scott A Harding; Peter D Larsen Journal: Heliyon Date: 2020-04-07