Margriet A B Veldhorst1, Gerard Noppe, Mieke H T M Jongejan, Chantine B M Kok, Selma Mekic, Jan Willem Koper, Elisabeth F C van Rossum, Erica L T van den Akker. 1. Department of Pediatrics (M.A.B.V., G.N., C.B.M.K., S.M., E.L.T.v.d.A.), Erasmus Medical Center (MC), Sophia Children's Hospital, 3000 CB Rotterdam, The Netherlands; Academic Medical Center Medical Research BV (M.A.B.V.), Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Department of Internal Medicine (G.N., J.W.K., E.F.C.v.R.), Division of Endocrinology, Erasmus MC, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands; Department of Pediatrics (M.H.T.M.J.), Sint Franciscus Gasthuis, Kleiweg 500, 3045 PM Rotterdam, The Netherlands; Obesity Center CGG, Erasmus MC and Sint Franciscus Gasthuis (M.A.B.V., G.N., M.H.T.M.J., C.B.M.K., S.M., J.W.K., E.F.C.v.R., E.L.T.v.d.A.), Rotterdam, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
Abstract
CONTEXT: Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. OBJECTIVE: The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children. DESIGN: We performed an observational case-control study. PARTICIPANTS: Twenty obese children (body mass index-SD score [BMI-SDS]>2.3) and 20 age- and sex-matched normal-weight children (BMI-SDS<1.1) aged 8-12 years were recruited. MAIN OUTCOME MEASURES: Scalp hair samples from the posterior vertex were collected, and hair cortisol concentrations were measured using ELISA. Body weight, height, and waist circumference were measured. From the obese children, additional data on blood pressure and blood lipid concentrations were collected. RESULTS: In both groups, five boys and 15 girls were included; their mean age was 10.8±1.3 vs 10.8±1.2 years (obese vs normal weight; not significant). Body weight, BMI, BMI-SDS, and waist circumference were higher in the obese children compared with the normal-weight children (69.8±17.2 vs 35.5±7.2 kg; 29.6±4.9 vs 16.4±1.6 kg/m2; 3.4±0.5 vs -0.2±0.8 SDS; 94±13 vs 62±6 cm; P<.001 all). Hair cortisol concentration was higher in obese than normal-weight children (median [interquartile range], 25 [17, 32] vs 17 [13, 21] pg/mg; P<.05). CONCLUSIONS: Hair cortisol concentration, a measure for long-term cortisol exposure, was higher in obese children than normal-weight children. This suggests long-term activation of the hypothalamus-pituitary-adrenal axis in obese children and may provide a novel target for treatment of obesity in children.
CONTEXT: Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. OBJECTIVE: The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children. DESIGN: We performed an observational case-control study. PARTICIPANTS: Twenty obesechildren (body mass index-SD score [BMI-SDS]>2.3) and 20 age- and sex-matched normal-weight children (BMI-SDS<1.1) aged 8-12 years were recruited. MAIN OUTCOME MEASURES: Scalp hair samples from the posterior vertex were collected, and hair cortisol concentrations were measured using ELISA. Body weight, height, and waist circumference were measured. From the obesechildren, additional data on blood pressure and blood lipid concentrations were collected. RESULTS: In both groups, five boys and 15 girls were included; their mean age was 10.8±1.3 vs 10.8±1.2 years (obese vs normal weight; not significant). Body weight, BMI, BMI-SDS, and waist circumference were higher in the obesechildren compared with the normal-weight children (69.8±17.2 vs 35.5±7.2 kg; 29.6±4.9 vs 16.4±1.6 kg/m2; 3.4±0.5 vs -0.2±0.8 SDS; 94±13 vs 62±6 cm; P<.001 all). Hair cortisol concentration was higher in obese than normal-weight children (median [interquartile range], 25 [17, 32] vs 17 [13, 21] pg/mg; P<.05). CONCLUSIONS: Hair cortisol concentration, a measure for long-term cortisol exposure, was higher in obesechildren than normal-weight children. This suggests long-term activation of the hypothalamus-pituitary-adrenal axis in obesechildren and may provide a novel target for treatment of obesity in children.
Authors: Aaron Hodes; Maya B Lodish; Amit Tirosh; Jerrold Meyer; Elena Belyavskaya; Charalampos Lyssikatos; Kendra Rosenberg; Andrew Demidowich; Jeremy Swan; Nichole Jonas; Constantine A Stratakis; Mihail Zilbermint Journal: Endocrine Date: 2017-02-13 Impact factor: 3.633
Authors: G Noppe; E L T van den Akker; Y B de Rijke; J W Koper; V W Jaddoe; E F C van Rossum Journal: Int J Obes (Lond) Date: 2016-06-24 Impact factor: 5.095
Authors: Monica R Ordway; Lois S Sadler; Craig A Canapari; Sangchoon Jeon; Nancy S Redeker Journal: Res Nurs Health Date: 2017-10-23 Impact factor: 2.228