Literature DB >> 24383846

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

Sita R Dewamitta1, Chacko Joseph, Louise E Purton, Carl R Walkley.   

Abstract

Vitamin A and its derivatives (retinoids) are important regulators of haematopoiesis, acting via retinoic acid receptors (RARs). Epidemiological studies indicated an association of vitamin A deficiency with anaemia in humans. To define the requirements of RARs in erythropoiesis, we evaluated erythroid parameters in RAR germ-line deficient and conditional knock out mice with erythroid specific deletion of RARs. Adult RARγ(-/-) mice were anaemic, however, Epor-Cre Rara(fl/fl) , Epor-Cre Rarg(fl/fl) and Epor-Cre Rara(fl/fl) g(fl/fl) mice were normal, indicating a lack of an erythroid intrinsic RAR function. Therefore, erythroid-specific RAR function is dispensable for erythropoiesis and RARγ plays an erythroid extrinsic role in erythropoiesis.
© 2013 John Wiley & Sons Ltd.

Entities:  

Keywords:  anaemia; erythroid development; experimental haematology; retinoic acid; vitamin A

Mesh：

Substances：

Year:  2013        PMID： 24383846     DOI： 10.1111/bjh.12578

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  8 in total

1.  Pathways of retinoid synthesis in mouse macrophages and bone marrow cells.

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2.  Influence of Dietary Vitamin A and Iron Deficiency on Hematologic Parameters and Body Weight of Young Male Wistar Rats.

Authors:  Mauricio Restrepo-Gallego; Luis E Díaz
Journal:  J Am Assoc Lab Anim Sci       Date:  2019-12-11       Impact factor: 1.232

3.  Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish.

Authors:  Diana M Mitchell; Craig B Stevens; Ruth A Frey; Samuel S Hunter; Ryuichi Ashino; Shoji Kawamura; Deborah L Stenkamp
Journal:  PLoS Genet       Date:  2015-08-21       Impact factor: 5.917

Review 4.  Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis.

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Journal:  Nutrients       Date:  2017-02-20       Impact factor: 5.717

Review 5.  RARG Gene Dysregulation in Acute Myeloid Leukemia.

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Journal:  Front Mol Biosci       Date:  2019-10-24

Review 6.  Role of Nuclear Receptors in Controlling Erythropoiesis.

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Journal:  Int J Mol Sci       Date:  2022-03-03       Impact factor: 5.923

7.  Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG.

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Journal:  Int J Mol Sci       Date:  2022-08-31       Impact factor: 6.208

8.  Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.

Authors:  Boris E Shmukler; Alicia Rivera; Katherine Nishimura; Ann Hsu; Jay G Wohlgemuth; Jeffrey S Dlott; L Michael Snyder; Carlo Brugnara; Seth L Alper
Journal:  Physiol Rep       Date:  2022-03
  8 in total

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