Y V Dumanskiy1, A G Kudriashov1, I V Vasilenko2, R B Kondratyuk2, Y K Gulkov2, R S Cyrillichystiakov3. 1. Department of Oncology, Maksim Gorky National Medical University, Donetsk 83092, Ukraine. 2. Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine. 3. Donetsk Regional Anticancer Center, Donetsk 83092, Ukraine.
Abstract
AIM: To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. METHODS: The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3-6 months) and a long-term survival group (17-24 months). EMT markers expression was assessed by immunohistochemical methods. RESULTS: It was determined that the rate of spindle-cell EMT was 96.4% in a short-term survival group and 42.1% in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3-4 occurred in 100% of cases in a short-term survival group versus 68.4% in a long-term survival group. CONCLUSION: The rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia.
AIM: To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. METHODS: The surgical material of 47 RCCpatients who underwent nephrectomy was studied. RCCpatients were distributed in two groups: a short-term survival group (3-6 months) and a long-term survival group (17-24 months). EMT markers expression was assessed by immunohistochemical methods. RESULTS: It was determined that the rate of spindle-cell EMT was 96.4% in a short-term survival group and 42.1% in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3-4 occurred in 100% of cases in a short-term survival group versus 68.4% in a long-term survival group. CONCLUSION: The rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia.