Treatment strategies of testicular cancer in the United States.

The treatment of testicular cancer has dramatically improved during the past decade. Combination chemotherapy with PVB was instituted at Indiana University in 1974. Subsequent studies demonstrated that: post PVB, surgery can cure patients; vinblastine dosage can be lowered from 0.4 to 0.3 mg/kg without sacrificing cure potential; maintenance vinblastine is not necessary; VP-16 can be substituted for vinblastine with equivalent cure rates and decreased neuromuscular toxicity.