Literature DB >> 2438161

Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its alpha-subunit.

J Codina, D Grenet, A Yatani, L Birnbaumer, A M Brown.   

Abstract

The resolved alpha-GTP gamma S (alpha*) and beta gamma-subunits of human erythrocyte Gk, the stimulatory regulatory component of hormone-responsive K+ channels, were tested for their potential stimulatory activities on the K+ channel of the endocrine GH3 cell. Concentrations as low as 0.5 pM alpha k* consistently activated K+ channels in isolated membrane patches, and saturating effects were obtained with 50 pM alpha k*. In contrast 2000-4000 pM beta gamma was without effect. We conclude that Gk acts on K+ channels through its alpha-subunit in a manner akin to that of Gs acting on adenylyl cyclase and transducin acting on cGMP-specific phosphodiesterase of photo-receptor cells.

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Year:  1987        PMID： 2438161     DOI： 10.1016/0014-5793(87)80765-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Inwardly rectifying potassium conductances in AtT-20 clonal pituitary cells.

Authors:  A G Dousmanis; P S Pennefather
Journal:  Pflugers Arch       Date:  1992-11       Impact factor: 3.657

Review 2.  Control of K+ channels by G proteins.

Authors:  A M Brown; A Yatani; G Kirsch; K Okabe; A M VanDongen; L Birnbaumer
Journal:  J Bioenerg Biomembr       Date:  1991-08       Impact factor: 2.945

3.  Guanine nucleotide-binding protein, alpha i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells.

Authors:  D B Light; D A Ausiello; B A Stanton
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

Review 4.  [Functional guanine nucleotide-binding proteins in receptor-mediated modulation of voltage-dependent ion channels].

Authors:  W Rosenthal; G Schultz
Journal:  Klin Wochenschr       Date:  1988-07-01

5.  Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes.

Authors:  N Dascal; N F Lim; W Schreibmayer; W Wang; N Davidson; H A Lester
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

6.  GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers.

Authors:  L Toro; J Ramos-Franco; E Stefani
Journal:  J Gen Physiol       Date:  1990-08       Impact factor: 4.086

7.  G-protein-mediated regulation of a Ca(2+)-dependent K+ channel in cultured vascular endothelial cells.

Authors:  L Vaca; W P Schilling; D L Kunze
Journal:  Pflugers Arch       Date:  1992-10       Impact factor: 3.657

8.  Modulation of membrane K+ conductance in T-lymphocytes by substance P via a GTP-binding protein.

Authors:  M A Schumann; P Gardner
Journal:  J Membr Biol       Date:  1989-10       Impact factor: 1.843

9.  Cyclic AMP-independent, dual regulation of voltage-dependent Ca2+ currents by LHRH and somatostatin in a pituitary cell line.

Authors:  W Rosenthal; J Hescheler; K D Hinsch; K Spicher; W Trautwein; G Schultz
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598
  9 in total

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