Literature DB >> 24380737

Decision rules for GHB (γ-hydroxybutyric acid) detoxification: a vignette study.

Rama M Kamal1, Sjacco van Iwaarden2, Boukje A G Dijkstra3, Cornelis A J de Jong4.   

Abstract

BACKGROUND: GHB dependent patients can suffer from a severe and sometimes life-threatening withdrawal syndrome. Therefore, most of the patients are treated within inpatient settings. However, some prefers an outpatient approach to treatment. The aim of this study was to develop decision rules for addiction physicians to determine whether an outpatient or inpatient setting should be chosen for a safe GHB detoxification.
METHODS: A prospective vignette study was performed. Forty addiction medicine specialists from various treatment settings and residents of the Addiction Medicine postgraduate Master training were asked to contribute vignettes of GHB dependent patients. A focus group of 15 psychiatrists and addiction medicine specialists was asked to recommend an outpatient or inpatient setting for GHB detoxification treatment per vignette. Finally, five addiction medicine specialists, experts in GHB dependence treatment in the Netherlands, assessed the bio-psychosocial reasons for the choices of the focus group and formulated the recommended criteria.
RESULTS: Based on the bio-psychosocial state of twenty vignette patients, addiction physicians and psychiatrists established the criteria and conditions recommended for the indication of an outpatient GHB detoxification. Intensity of addiction (GHB dose ≤32 g/d and frequency of abuse ≤2 h) was stated as the primary criterion in determining the setting as well as the complexity of the psychiatric comorbid disorders. The importance of a stable support system was emphasised.
CONCLUSION: The vignette study resulted in a set of criteria with which addiction medicine specialists can make a weighted decision as to an outpatient or inpatient setting for GHB detoxification.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Detoxification; GHB; Gamma-hydroxybutyric acid; Outpatient; Vignette study

Mesh:

Substances:

Year:  2013        PMID: 24380737     DOI: 10.1016/j.drugalcdep.2013.12.003

Source DB:  PubMed          Journal:  Drug Alcohol Depend        ISSN: 0376-8716            Impact factor:   4.492


  3 in total

Review 1.  Pharmacological Treatment in γ-Hydroxybutyrate (GHB) and γ-Butyrolactone (GBL) Dependence: Detoxification and Relapse Prevention.

Authors:  Rama M Kamal; Martijn S van Noorden; Wim Wannet; Harmen Beurmanjer; Boukje A G Dijkstra; Arnt Schellekens
Journal:  CNS Drugs       Date:  2017-01       Impact factor: 5.749

2.  Inpatient Gamma-Hydroxybutyrate Detoxification: A Case Report Describing Day-to-day Therapeutic Management.

Authors:  Louis von Theobald; Morgane Rousselet; Jennyfer Cholet; Hélène Debar; David Boels; Caroline Victorri-Vigneau; Marie Grall-Bronnec
Journal:  J Addict Med       Date:  2017 May/Jun       Impact factor: 3.702

Review 3.  Metabolic Alterations Associated with γ-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure.

Authors:  Suryun Jung; Suji Kim; Yujin Seo; Sooyeun Lee
Journal:  Metabolites       Date:  2021-02-10
  3 in total

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