Literature DB >> 24379924

Diabetic macular edema: New promising therapies.

Hanan N Al Shamsi1, Jluwi S Masaud1, Nicola G Ghazi1.   

Abstract

The treatment of diabetic macular edema is rapidly evolving. The era of laser therapy is being quickly replaced by an era of pharmacotherapy. Several pharmacotherapies have been recently developed for the treatment of retinal vascular diseases such as diabetic macular edema. Several intravitreal injections or sustained delivery devices have undergone phase 3 testing while others are currently being evaluated. The results of clinical trials have shown the superiority of some of these agents to laser therapy. However, with the availability of several of these newer agents, it may be difficult to individualize treatment options especially those patients respond differently to various therapies. As such, more effort is still needed in order to determine the best treatment regimen for a given patient. In this article, we briefly summarize the major new therapeutic additions for the treatment of diabetic macular edema and allude to some future promising therapies.

Entities:  

Keywords:  Diabetic macular edema; Diabetic retinopathy; Intravitreal injection; Laser photocoagulation; Pharmacotherapy; Sustained release drug delivery devices; Vitrectomy

Year:  2013        PMID: 24379924      PMCID: PMC3874493          DOI: 10.4239/wjd.v4.i6.324

Source DB:  PubMed          Journal:  World J Diabetes        ISSN: 1948-9358


  150 in total

1.  Argon green (514 nm) versus krypton red (647 nm) modified grid laser photocoagulation for diffuse diabetic macular edema.

Authors:  R J Olk
Journal:  Ophthalmology       Date:  1990-09       Impact factor: 12.079

2.  intravitreal tumor necrosis factor inhibitors in the treatment of refractory diabetic macular edema: a pilot study from the Pan-American Collaborative Retina Study Group.

Authors:  Lihteh Wu; Erick Hernandez-Bogantes; José A Roca; J Fernando Arevalo; Karen Barraza; Andres F Lasave
Journal:  Retina       Date:  2011-02       Impact factor: 4.256

3.  Clinical examination accurately locates capillary nonperfusion in diabetic retinopathy.

Authors:  James A Kimble; Bari M Brandt; Gerald McGwin
Journal:  Am J Ophthalmol       Date:  2005-03       Impact factor: 5.258

4.  The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology.

Authors:  E Stefánsson
Journal:  Acta Ophthalmol Scand       Date:  2001-10

5.  Intravitreal triamcinolone for diabetic macular edema that persists after laser treatment: three-month efficacy and safety results of a prospective, randomized, double-masked, placebo-controlled clinical trial.

Authors:  Florian K P Sutter; Judy M Simpson; Mark C Gillies
Journal:  Ophthalmology       Date:  2004-11       Impact factor: 12.079

Review 6.  Subthreshold and micropulse diode laser photocoagulation.

Authors:  Giorgio Dorin
Journal:  Semin Ophthalmol       Date:  2003-09       Impact factor: 1.975

7.  Role of the vitreous in cystoid macular edema.

Authors:  C L Schepens; M P Avila; A E Jalkh; C L Trempe
Journal:  Surv Ophthalmol       Date:  1984-05       Impact factor: 6.048

8.  Effects of macular ischemia on the outcome of intravitreal bevacizumab therapy for diabetic macular edema.

Authors:  Eun Jee Chung; Mi In Roh; Oh Woong Kwon; Hyoung Jun Koh
Journal:  Retina       Date:  2008 Jul-Aug       Impact factor: 4.256

9.  Primary End Point (Six Months) Results of the Ranibizumab for Edema of the mAcula in diabetes (READ-2) study.

Authors:  Quan Dong Nguyen; Syed Mahmood Shah; Jeffery S Heier; Diana V Do; Jennifer Lim; David Boyer; Prema Abraham; Peter A Campochiaro
Journal:  Ophthalmology       Date:  2009-08-22       Impact factor: 12.079

10.  Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.

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Journal:  N Engl J Med       Date:  1994-12-01       Impact factor: 91.245

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  8 in total

Review 1.  Recent progress in the genetics of diabetic microvascular complications.

Authors:  Yi-Cheng Chang; Emily Yun-Chia Chang; Lee-Ming Chuang
Journal:  World J Diabetes       Date:  2015-06-10

Review 2.  Effectiveness of the Dexamethasone Intravitreal Implant for Treatment of Patients with Diabetic Macular Oedema.

Authors:  Marco Dutra Medeiros; Micol Alkabes; Paolo Nucci
Journal:  Eur Endocrinol       Date:  2014-08-28

3.  Planned foveal detachment technique for the resolution of diffuse diabetic macular edema.

Authors:  Yuki Morizane; Shuhei Kimura; Mio Hosokawa; Yusuke Shiode; Masayuki Hirano; Shinichiro Doi; Mika Hosogi; Atsushi Fujiwara; Yasushi Inoue; Fumio Shiraga
Journal:  Jpn J Ophthalmol       Date:  2015-07-30       Impact factor: 2.447

Review 4.  Diabetic Retinopathy and Diabetic Macular Edema.

Authors:  Steven R Cohen; Thomas W Gardner
Journal:  Dev Ophthalmol       Date:  2015-10-26

Review 5.  Advances in diabetic retinopathy.

Authors:  Prakashchand Agarwal; Ankita Jindal; V K Saini; Sushil Jindal
Journal:  Indian J Endocrinol Metab       Date:  2014-11

6.  Clinical observation of the efficacy of Bevacizumab combined with argon green laser in treating fundus macular edema.

Authors:  Yi Shao; Yao Yu; Cheng Li; Chong-Gang Pei; Ping Tu; Yun Han; Gui-Ping Gao
Journal:  Exp Ther Med       Date:  2017-02-21       Impact factor: 2.447

7.  Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells.

Authors:  Shengyu Wu; Xiaolu Zhu; Biechuan Guo; Tian Zheng; Jiangbo Ren; Wen Zeng; Xiaomin Chen; Min Ke
Journal:  J Ophthalmol       Date:  2019-02-24       Impact factor: 1.909

8.  Six-month postoperative outcomes of intraoperative OCT-guided surgical cystotomy for refractory cystoid macular edema in diabetic eyes.

Authors:  Yuichi Asahina; Naoko Tachi; Yumi Asahina; Kayoko Yoshimura; Yoshiki Ueta; Yoshihiro Hashimoto
Journal:  Clin Ophthalmol       Date:  2017-11-23
  8 in total

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