| Literature DB >> 24379657 |
Mia Conradsson1, Håkan Littbrand2, Gustaf Boström1, Nina Lindelöf1, Yngve Gustafson1, Erik Rosendahl2.
Abstract
AIM: Functional capacity and dependency in activities of daily living (ADL) could be important mediators for an association between physical exercise and mental health. The aim of this study was to investigate whether a change in functional capacity or dependency in ADL is associated with a change in depressive symptoms and psychological well-being among older people living in residential care facilities, and whether dementia can be a moderating factor for this association.Entities:
Keywords: activities of daily living; aged; dementia; depression; frail elderly; mental health; physical fitness; quality of life; residential facilities
Mesh:
Year: 2013 PMID: 24379657 PMCID: PMC3843606 DOI: 10.2147/CIA.S53270
Source DB: PubMed Journal: Clin Interv Aging ISSN: 1176-9092 Impact factor: 4.458
Figure 1Flowchart of the participants.
Notes: aParticipants were derived from the Frail Older People – Activity and Nutrition Study in Umeå (FOPANU study) and the Residential care facilities – Mobility, Activity, and Nutrition Study in Umeå (REMANU study); ba number of individuals (n=18) participated in both studies; for these individuals, only data from the FOPANU study were used; ctarget variables include the Berg Balance Scale, the Barthel ADL Index, the Geriatric Depression Scale, and the Philadelphia Geriatric Center Morale Scale.
Abbreviations: ADL, activities of daily living; MMSE, Mini Mental State Examination.
Baseline characteristics of the participants
| Characteristic | Total (n=206) | Dementia (n=115) | No dementia (n=91) |
|---|---|---|---|
| Age, mean ± SD (range) | 84.3±6.6 | 84.1±5.9 | 84.6±7.3 |
| Female sex, n (%) | 153 (74) | 87 (76) | 66 (73) |
| Depression | 122 (59) | 68 (59) | 54 (59) |
| Previous stroke | 51 (25) | 16 (14) | 35 (39) |
| Previous urinary tract infection, last year | 82 (40) | 43 (37) | 39 (43) |
| Constipation, last month | 108 (52) | 53 (46) | 55 (60) |
| Diabetes mellitus | 34 (17) | 18 (16) | 16 (18) |
| Heart failure | 59 (29) | 24 (21) | 35 (39) |
| Angina pectoris | 68 (28) | 29 (25) | 29 (32) |
| Hip fracture, last 5 years | 29 (14) | 14 (12) | 15 (17) |
| Osteoporosis | 60 (29) | 34 (30) | 26 (29) |
| Malignancy, last 5 years | 23 (11) | 8 (7) | 15 (17) |
| Urinary incontinence | 91 (44) | 49 (43) | 42 (46) |
| Diuretics | 102 (50) | 56 (40) | 56 (62) |
| Analgesics | 119 (58) | 63 (55) | 56 (62) |
| Benzodiazepines | 80 (39) | 39 (34) | 41 (45) |
| Antidepressants | 101 (49) | 58 (50) | 43 (47) |
| Neuroleptics | 52 (25) | 31 (27) | 21 (23) |
| Acetylcholinesterase inhibitors | 29 (14) | 29 (25) | 0 |
| Number of drugs for regular use, mean ± SD (range) | 9.1±4.1 | 8.2±3.8 | 10.2±4.1 |
| Visual impairment, n (%) | 51 (25) | 30 (26) | 21 (23) |
| Hearing impaired, n (%) | 31 (15) | 16 (14) | 15 (17) |
| Fall, last 6 months, n (%) | 79 (42) | 39 (38) | 40 (49) |
| MMSE, mean ± SD (range) | 18.0±5.2 | 16.1±4.9 | 20.4±4.5 |
| MNA, mean ± SD (range) | 20.5±3.6 | 20.8±3.5 | 20.2±3.8 |
| Health, self-perceived as better than age peers, n (%) | 86 (42) | 53 (46) | 33 (36) |
| Independent gait indoors with or without walking aid | 135 (66) | 81 (70) | 54 (60) |
Notes: Numbers after a characteristic indicate that there are missing assessments.
Assessed with Barthel ADL Index
assessed with the MNA.
Abbreviations: ADL, activities of daily living; MMSE, Mini Mental State Examination; MNA, Mini Nutritional Assessment scale; SD, standard deviation.
Univariate and multivariate linear regression for associations between differences in BBS and GDS-15, or PGCMS, respectively, as well as between differences in Barthel ADL Index and GDS-15, or PGCMS, respectively. Each analysis in the multivariate model was evaluated for interaction of dementia disorder
| Univariate analyses
| Multivariate analyses
| ||||||
|---|---|---|---|---|---|---|---|
| n | Unstandardized β (95% CI) | Unstandardized β (95% CI) | Interaction dementia ( | ||||
| Berg Balance Scale | 196 | 0.012 (−0.038–0.063) | 0.63 | Berg Balance Scale | 0.026 (−0.024–0.075) | 0.31 | 0.54 |
| Barthel ADL Index | 201 | 0.087 (−0.041–0.214) | 0.18 | Barthel ADL Index | 0.123 (−0.004–0.249) | 0.06 | 1.00 |
| Berg Balance Scale | 201 | 0.052 (−0.007–0.111) | 0.09 | Berg Balance Scale | 0.045 (−0.014–0.103) | 0.14 | 0.89 |
| Barthel ADL Index | 206 | 0.003 (−0.143–0.150) | 0.97 | Barthel ADL Index | −0.013 (−0.160–0.134) | 0.86 | 0.21 |
Notes: Dependent variables were difference in GDS-15 or difference in PGCMS, respectively. Independent variables were difference in BBS or Barthel ADL Index. The multivariate linear regression was adjusted for age, sex, and baseline characteristics with univariate associations to the dependent variable (P≤0.15), evaluated in each sample. Participants with sufficient data formed the sample for each separate analysis. Interaction for dementia was tested by including dementia and the product of the difference in BBS or Barthel ADL Index and dementia as independent variables in each multivariate model.
Adjusted for age, sex, diagnosis of depression, previous stroke, diabetes mellitus, heart failure, angina pectoris, and osteoporosis
adjusted for age, sex, diagnosis of depression, previous stroke, diabetes mellitus, angina pectoris, and osteoporosis
adjusted for age, sex, previous stroke, heart failure, malignancy in last 5 years, and independent gait indoors
adjusted for age, sex, previous stroke, heart failure, and malignancy in last 5 years.
Abbreviations: ADL, activities of daily living; BBS, Berg Balance Scale; CI, confidence interval, GDS-15, Geriatric Depression Scale, 15-item version; PGCMS, Philadelphia Geriatric Center Morale Scale.
Baseline values and differences for the following target variables: Berg Balance Scale, Barthel ADL Index, Geriatric Depression Scale, and Philadelphia Geriatric Center Morale Scale
| Target variable, mean ± SD (range) | n | Total | n | Dementia | n | No dementia |
|---|---|---|---|---|---|---|
| Berg Balance Scale | 204 | 27.9±15.2 (1–55) | 113 | 32.0±14.3 (2–55) | 91 | 22.7±14.6 (1–50) |
| Barthel ADL Index | 206 | 13.3±4.3 (1–19) | 115 | 14.1±3.9 (3–19) | 91 | 12.2±4.5 (1–18) |
| Geriatric Depression Scale | 203 | 4.3±3.0 (0–14) | 114 | 3.7±2.8 (0–14) | 89 | 5.0±3.2 (0–14) |
| Philadelphia Geriatric Centre Morale Scale | 206 | 11.1±3.5 (2–17) | 115 | 11.7±3.3 (2–17) | 91 | 10.4±3.6 (3–17) |
| Berg Balance Scale | 201 | 1.6±6.0 (−21–20) | 111 | 1.2±5.9 (−21–14) | 90 | 2.0±6.2 (−17–20) |
| Barthel ADL Index | 206 | −0.4±2.4 (−12–6) | 115 | −0.6±2.1 (−7–5) | 91 | −0.2±2.7 (−12–6) |
| Geriatric Depression Scale | 201 | 0.00±2.2 (−6–7) | 114 | −0.04±2.4 (−6–6) | 87 | 0.06±1.9 (−6–7) |
| Philadelphia Geriatric Centre Morale Scale | 206 | 0.1±2.6 (−12–7) | 115 | 0.03±2.8 (−12–7) | 91 | 0.3±2.3 (−7–6) |
| Berg Balance Scale | 201 | 4.7±4.1 (0–21) | 111 | 4.5±4.0 (0–21) | 90 | 4.8±4.4 (0–20) |
| Barthel ADL Index | 206 | 1.7±1.8 (0–12) | 115 | 1.5±1.6 (0–7) | 91 | 1.9±2.0 (0–12) |
| Geriatric Depression Scale | 201 | 1.6±1.5 (0–7) | 114 | 1.7±1.7 (0–6) | 87 | 1.4±1.3 (0–7) |
| Philadelphia Geriatric Centre Morale Scale | 206 | 1.8±1.8 (0–12) | 115 | 2.0±1.9 (0–12) | 91 | 1.6±1.6 (0–7) |
Notes: For all assessment scales, except the Geriatric Depression Scale, a higher score indicates higher function or mental health. A negative difference in the Geriatric Depression Scale scores indicates a reduction in depressive symptoms, and a positive difference in the Philadelphia Geriatric Centre Morale Scale scores indicates increased psychological well-being. A positive difference for the Berg Balance Scale and Barthel ADL Index indicates better functional capacity or decreased dependency in ADL at follow-up, respectively.
Abbreviations: ADL, activities of daily living; SD, standard deviation.
Figure 2Scatterplots of the differences in scores (follow-up value minus baseline values) in BBS versus GDS-15 (r2=0.001, P=0.63) and PGCMS (r2=0.02, P=0.09), respectively, and likewise, difference in Barthel ADL Index versus GDS-15 (r2=0.009, P=0.18) and PGCMS (r2<0.001, P=0.97), respectively. For all assessment scales except the GDS-15, a positive difference indicates improved function or mental health from baseline to follow-up. A single dot can represent one or more individuals.
Abbreviations: ADL, activities of daily living; BBS, Berg Balance Scale; GDS-15, Geriatric Depression Scale 15-item version; PGCMS, Philadelphia Geriatric Center Morale Scale.