Sir,The new emerging H7N9 infection in several provinces of China leads to the worldwide discussion on this possible new global threaten.[1] As an atypical influenza virus infection, there are many atypical clinical presentations adding to simple respiratory signs and symptoms. In psychological medicine, the question is whether there is any psychological presentation of H7N9 infection. Of interest, on available data, the observation on “confusion” in some patients is described (see www.flu.gov for more information). The neurological involvement of H7N9 infection is widely discussed and believed to be a possible explanation for rapid deterioration of mental status in some infected cases.[2] To correspond for the possible worldwide epidemic of H7N9 infection, the concern that the psychological manifestation might be the first presentation must be kept in mind of all practitioners.