Literature DB >> 24379199

Disruption of biofilm formation by the human pathogen Acinetobacter baumannii using engineered quorum-quenching lactonases.

Jeng Yeong Chow1, Yuanyong Yang, Song Buck Tay, Kim Lee Chua, Wen Shan Yew.   

Abstract

Acinetobacter baumannii is a major human pathogen associated with multidrug-resistant nosocomial infections; its virulence is attributed to quorum-sensing-mediated biofilm formation, and disruption of biofilm formation is an attractive antivirulence strategy. Here, we report the first successful demonstration of biofilm disruption in a clinical isolate of A. baumannii S1, using a quorum-quenching lactonase obtained by directed evolution; this engineered lactonase significantly reduced the biomass of A. baumannii-associated biofilms, demonstrating the utility of this antivirulence strategy.

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Year:  2013        PMID： 24379199      PMCID： PMC3957888          DOI： 10.1128/AAC.02410-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Custom synthesis of autoinducers and their analogues.

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Journal:  Methods Mol Biol       Date:  2011

2.  Characterization of a phosphotriesterase-like lactonase from Sulfolobus solfataricus and its immobilization for disruption of quorum sensing.

Authors:  Filomena S W Ng; Daniel M Wright; Stephen Y K Seah
Journal:  Appl Environ Microbiol       Date:  2010-12-23       Impact factor: 4.792

Review 3.  Antibiotic resistance in community-acquired pneumonia caused by Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii.

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Journal:  Chest       Date:  2009-10       Impact factor: 9.410

4.  Genetic analysis of surface motility in Acinetobacter baumannii.

Authors:  Katy M Clemmer; Robert A Bonomo; Philip N Rather
Journal:  Microbiology (Reading)       Date:  2011-06-23       Impact factor: 2.777

Review 5.  Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options.

Authors:  Marie Kempf; Jean-Marc Rolain
Journal:  Int J Antimicrob Agents       Date:  2011-11-22       Impact factor: 5.283

Review 6.  Quorum sensing in Acinetobacter: an emerging pathogen.

Authors:  Nidhi Bhargava; Prince Sharma; Neena Capalash
Journal:  Crit Rev Microbiol       Date:  2010-11       Impact factor: 7.624

7.  Directed evolution of a quorum-quenching lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the amidohydrolase superfamily.

Authors:  Jeng Yeong Chow; Long Wu; Wen Shan Yew
Journal:  Biochemistry       Date:  2009-05-26       Impact factor: 3.162

8.  Regulation of Acinetobacter baumannii biofilm formation.

Authors:  Jennifer A Gaddy; Luis A Actis
Journal:  Future Microbiol       Date:  2009-04       Impact factor: 3.165

9.  Functional annotation and three-dimensional structure of Dr0930 from Deinococcus radiodurans, a close relative of phosphotriesterase in the amidohydrolase superfamily.

Authors:  Dao Feng Xiang; Peter Kolb; Alexander A Fedorov; Monika M Meier; Lena V Fedorov; T Tinh Nguyen; Reinhard Sterner; Steven C Almo; Brian K Shoichet; Frank M Raushel
Journal:  Biochemistry       Date:  2009-03-17       Impact factor: 3.162

10.  The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

Authors:  Robert C Kelly; Megan E Bolitho; Douglas A Higgins; Wenyun Lu; Wai-Leung Ng; Philip D Jeffrey; Joshua D Rabinowitz; Martin F Semmelhack; Frederick M Hughson; Bonnie L Bassler
Journal:  Nat Chem Biol       Date:  2009-10-18       Impact factor: 15.040
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  26 in total

1.  Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens.

Authors:  Erin E Gill; Octavio L Franco; Robert E W Hancock
Journal:  Chem Biol Drug Des       Date:  2015-01       Impact factor: 2.817

2.  Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii.

Authors:  Sean D Stowe; Richele J Thompson; Lingling Peng; Zhaoming Su; Meghan S Blackledge; G Logan Draughn; William H Coe; Eva Johannes; Valerie K Lapham; John Mackenzie; Christian Melander; John Cavanagh
Journal:  Curr Drug Deliv       Date:  2015       Impact factor: 2.565

Review 3.  Quorum quenching enzymes and their effects on virulence, biofilm, and microbiomes: a review of recent advances.

Authors:  Rakesh Sikdar; Mikael Elias
Journal:  Expert Rev Anti Infect Ther       Date:  2020-08-04       Impact factor: 5.091

4.  Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to elongation factor EF-Tu reveals a novel protein interaction site.

Authors:  Lakshmanane Premkumar; Fabian Kurth; Wilko Duprez; Morten K Grøftehauge; Gordon J King; Maria A Halili; Begoña Heras; Jennifer L Martin
Journal:  J Biol Chem       Date:  2014-05-23       Impact factor: 5.157

5.  Antivirulence Agent as an Adjuvant of β-Lactam Antibiotics in Treating Staphylococcal Infections.

Authors:  Peng Gao; Yuanxin Wei; Sherlock Shing Chiu Tai; Pradeep Halebeedu Prakash; Ho Ting Venice Iu; Yongli Li; Hin Cheung Bill Yam; Jonathan Hon Kwan Chen; Pak Leung Ho; Julian Davies; Richard Yi Tsun Kao
Journal:  Antibiotics (Basel)       Date:  2022-06-17

6.  Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases.

Authors:  Song Buck Tay; Jeng Yeong Chow; Maybelle Kho Go; Wen Shan Yew
Journal:  J Vis Exp       Date:  2016-01-01       Impact factor: 1.355

Review 7.  Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control.

Authors:  Raphaël Billot; Laure Plener; Pauline Jacquet; Mikael Elias; Eric Chabrière; David Daudé
Journal:  J Biol Chem       Date:  2020-07-20       Impact factor: 5.157

8.  Enhancing pili assembly and biofilm formation in Acinetobacter baumannii ATCC19606 using non-native acyl-homoserine lactones.

Authors:  Li-mei Luo; Li-juan Wu; Yu-ling Xiao; Dan Zhao; Zhi-xing Chen; Mei Kang; Qi Zhang; Yi Xie
Journal:  BMC Microbiol       Date:  2015-03-07       Impact factor: 3.605

Review 9.  Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing.

Authors:  Natalie K Boyd; Chengwen Teng; Christopher R Frei
Journal:  Front Cell Infect Microbiol       Date:  2021-05-17       Impact factor: 5.293

Review 10.  Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens.

Authors:  Song Buck Tay; Wen Shan Yew
Journal:  Int J Mol Sci       Date:  2013-08-09       Impact factor: 5.923
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