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Literature DB >> 24379143

Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies.

Abstract

The hemostatic system is an important player in host's response to infection. It has been shown that host hemostatic factors as well as platelets, interact with various proteins from bacteria and play important roles in host defense against infections. This review summarizes studies of function of host hemostatic system in host defense against bacterial infections and efforts to target hemostatic system interaction with pathogens to develop potential antimicrobial therapies.

Entities: Disease

Mesh：

Substances：
Anti-Infective Agents

Year: 2014 PMID： 24379143 DOI： 10.1007/s11239-013-0994-9

Source DB: PubMed Journal: J Thromb Thrombolysis ISSN： 0929-5305 Impact factor: 2.300

Keyword Cloud
References

85 in total

1. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis.

Authors: D E Joyce; L Gelbert; A Ciaccia; B DeHoff; B W Grinnell
Journal: J Biol Chem Date: 2001-02-05 Impact factor: 5.157

Review 2. Platelets as immune cells: bridging inflammation and cardiovascular disease.

Authors: Philipp von Hundelshausen; Christian Weber
Journal: Circ Res Date: 2007-01-05 Impact factor: 17.367

3. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

Authors: Juliane Bubeck Wardenburg; Taeok Bae; Michael Otto; Frank R Deleo; Olaf Schneewind
Journal: Nat Med Date: 2007-12 Impact factor: 53.440

4. Recombinant human activated protein C as a therapy for severe sepsis: lessons learned?

Authors: Steven M Opal; Steven P LaRosa
Journal: Am J Respir Crit Care Med Date: 2013-05-15 Impact factor: 21.405

5. Antimicrobial peptides from human platelets.

Authors: Yi-Quan Tang; Michael R Yeaman; Michael E Selsted
Journal: Infect Immun Date: 2002-12 Impact factor: 3.441

6. Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement.

Authors: A H Patel; P Nowlan; E D Weavers; T Foster
Journal: Infect Immun Date: 1987-12 Impact factor: 3.441

Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies.

1. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis.

Review 2. Platelets as immune cells: bridging inflammation and cardiovascular disease.

3. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia.

4. Recombinant human activated protein C as a therapy for severe sepsis: lessons learned?

5. Antimicrobial peptides from human platelets.

6. Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement.

7. A role for fibrinogen in the streptokinase-dependent acquisition of plasmin(ogen) by group A streptococci.

Review 8. Fibrin and fibrinolysis in infection and host defense.

9. Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injury.

10. Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation.