| Literature DB >> 24379014 |
Robel Iyassu1, Suzanne Jolley, Paul Bebbington, Graham Dunn, Richard Emsley, Daniel Freeman, David Fowler, Amy Hardy, Helen Waller, Elizabeth Kuipers, Philippa Garety.
Abstract
PURPOSE: Religious delusions are common and are considered to be particularly difficult to treat. In this study we investigated what psychological processes may underlie the reported treatment resistance. In particular, we focused on the perceptual, cognitive, affective and behavioural mechanisms held to maintain delusions in cognitive models of psychosis, as these form the key treatment targets in cognitive behavioural therapy. We compared religious delusions to delusions with other content.Entities:
Mesh:
Year: 2013 PMID: 24379014 PMCID: PMC4173112 DOI: 10.1007/s00127-013-0811-y
Source DB: PubMed Journal: Soc Psychiatry Psychiatr Epidemiol ISSN: 0933-7954 Impact factor: 4.328
Demographic and clinical characteristics of participants with religious delusions compared to those with other delusions
| Total sample ( | Religious delusions ( | Other delusions ( |
|
| |
|---|---|---|---|---|---|
| Age (years) | |||||
| Mean (SD) | 38.9 (11.3) | 38.9 (10.6) | 38.9 (11.7) | −0.03 (381) | 1.0 |
| Length of illness (years) | |||||
| Mean (SD) | 11.9 (9.6) | 13.3 (10.4) | 11.5 (9.4) | −1.5 (375) | 0.1 |
aChlorpromazine equivalent, 0–200 = low; 201–400 = medium; >400 = high
Binary logistic regression showing the prevalence of delusional subtypes between participants with religious delusions compared to those with other delusions (with percentage prevalence rates for each group)
| Delusion subtype | Age prevalence (%) | OR | 95 % CI |
| ||
|---|---|---|---|---|---|---|
| Total sample ( | Religious delusions ( | Other delusions ( | ||||
| Persecutory delusions | 80 | 69 | 83 | 0.7a | 0.3–1.2 | 0.2 |
| Delusions of reference | 68 | 71 | 67 | 1.0 | 0.5–1.8 | 0.9 |
| Delusions of mind reading | 40 | 48 | 38 | 1.4 | 0.8–2.5 | 0.3 |
| Delusions of sin and guilt | 12 | 16 | 11 | 2.2b | 1.0–4.8 | 0.04 |
| Grandiose delusions | 30 | 59 | 21 | 6.2 | 3.5–11.1 | <0.001 |
| Religious delusions | 21 | 100 | 0 | |||
| Thought insertion | 20 | 26 | 19 | 1.1 | 0.5–2.4 | 0.8 |
| Somatic delusions | 19 | 21 | 18 | 1.0 | 0.5–2.1 | 0.8 |
| Thought broadcast | 18 | 21 | 17 | 0.9 | 0.4–2.0 | 0.8 |
| Delusions of being controlled | 18 | 29 | 15 | 3.1 | 1.5–6.2 | 0.002 |
| Thought withdrawal | 7 | 10 | 6 | 1.2 | 0.4–3.3 | 0.8 |
| Delusions of jealousy | 2 | 1 | 2 | 0.6 | 0.1–5.8 | 0.7 |
OR odds ratio, CI confidence intervals
aUncontrolled analyses suggest RD group less likely to experience persecutory delusions (OR 0.4, 95 % CI 0.3–0.8, p = 0.004)
bNo association in uncontrolled analyses (OR 1.5, 95 % CI 0.7–2.9, p = 0.2)
Psychotic symptoms, delusional conviction and engagement scores in participants with religious delusions compared to those with other types of delusions
| Variable | Religious delusions ( | Other delusions ( |
|
|
|
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | ||||
| SAPS positive symptoms | |||||
| SAPS total | 9.3 (2.7) | 8.0 (3.1) | −3.5, 0.4 | 378 | <0.001 |
| Hallucinations | 3.1 (1.7) | 2.6 (1.8) | −2.2, 0.3 | 379 | 0.03 |
| Delusions | 4 (0.8) | 3.8 (0.8) | −1.9, 0.2 | 381 | 0.06 |
| Bizarre behaviour | 1.1 (1.1) | 0.7 (1.0) | −2.6, 0.4 | 381 | <0.01 |
| Formal thought disorder | 1.2 (1.2) | 0.9 (1.3) | −2.0, 0.3 | 380 | <0.05 |
| SANS negative symptoms | |||||
| SANS total | 6.7 (4.3) | 7.9 (4.4) | 2.3, −0.3 | 379 | 0.02 |
| Affective flattening | 1.0 (1.4) | 1.1 (1.3) | 0.4 | 381 | 0.7 |
| Alogia | 0.4 (0.9) | 0.6 (1.1) | 1.8, −0.2 | 168b | 0.04 |
| Anhedonia–asociality | 2.1 (1.5) | 2.4 (1.5) | 2.0, −0.2 | 380 | 0.04 |
| Attention | 1.2 (1.1) | 1.4 (1.6) | 1.3 | 380 | 0.2 |
| Avolition–apathy | 2.0 (1.4) | 2.4 (1.4) | 2.2, −0.3 | 381 | 0.03 |
| Conviction | |||||
| PSYRATS score | 3.3 (0.9) | 3.1 (1.1) | −1.5 | 376 | 0.1 |
SAPS/SANS scale for the assessment of positive/negative symptoms, PSYRATS Psychotic Symptoms Rating Scales, MARS Medication Adherence Rating Scale, CBT cognitive behavioural therapy, ES effect size, Cohen’s d [55]
aOnly available for data from CBT intervention arm of PRP trial
bSatterthwaite adjustment carried out
Anomalous experiences, affect and reasoning biases in religious delusions compared to other types of delusions
| Variable | Religious delusions ( | Other delusions ( |
|
|
|
|---|---|---|---|---|---|
|
|
| ||||
| Anomalous experiences | |||||
| Yes | 66 (75.9) | 182 (61.7) | 5.9, 0.1 | 1 | 0.02 |
| No | 21 (24.1) | 113 (38.3) | |||
| Internal state | |||||
| Yes | 72 (90) | 204(80.3) | 4.0, 0.1 | 1 | 0.05 |
| No | 8 (10) | 50 (19.7) | |||
| External state | |||||
| Yes | 46 (57.5) | 173 (68.7) | 3.4 | 1 | 0.07 |
| No | 34 (42.5) | 79 (31.3) | |||
BDI beck depression inventory, BAI beck anxiety inventory, JTC jumping to conclusions, IPQ Illness Perceptions Questionnaire, ES effect size, r [55]
aOnly available for data from PRP trial
Final model of the binary logistic regression analysis illustrating the predictors of religious delusions
| Independent variable | OR | 95 % CI |
|
|---|---|---|---|
| Grandiose delusions | 7.5 | 3.9–14.1 | <0.001 |
| Delusions of being controlled | 3.2 | 1.5–6.6 | 0.002 |
| Bizarre behaviour | 1.3 | 1.0–1.7 | 0.07 |
| Avolition/apathy | 0.8 | 0.6–1.0 | 0.02 |
| Alternative explanations | 2.2 | 1.1–4.2 | 0.02 |
| Internal evidence | 3.4 | 1.3–8.6 | 0.01 |
OR odds ratio, CI confidence intervals