| Literature DB >> 24377749 |
Nadezhda V Palysaeva1, Katerina P Kumpan, Marina I Struchkova, Igor L Dalinger, Aleksandr V Kormanov, Nataly S Aleksandrova, Victor M Chernyshev, Dmitrii F Pyreu, Kyrill Yu Suponitsky, Aleksei B Sheremetev.
Abstract
The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.Entities:
Year: 2013 PMID： 24377749 DOI： 10.1021/ol403308h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005