Literature DB >> 24377378

Bioactivity and potential health benefits of licorice.

Tzu-Chien Kao1, Chi-Hao Wu, Gow-Chin Yen.   

Abstract

Licorice is an herbal plant named for its unique sweet flavor. It is widely used in the food and tobacco industries as a sweetener. Licorice is also used in traditional Chinese medicine (TCM) and complementary medicine. Because the use of licorice has long been a part of TCM, the details of its therapeutic applications have been thoroughly established. In modern science, licorice is of interest because of its broad range of applications. Extracts of and compounds isolated from licorice have been well studied and biologically characterized. In this review, we discuss the nutraceutical and functional activities of licorice as well as those of the extracts of and the isolated compounds from licorice, including agents with anti-inflammatory activity, cell-protective abilities, and chemopreventive effects. The side effects of licorice are also enumerated. A comparison of the activities of licorice described by modern science and TCM is also presented, revealing the correspondence of certain characteristics.

Entities:  

Keywords:  18β-glycyrrhetinic acid; biological function; glycyrrhizic acid; licorice; safety

Mesh:

Substances:

Year:  2014        PMID: 24377378     DOI: 10.1021/jf404939f

Source DB:  PubMed          Journal:  J Agric Food Chem        ISSN: 0021-8561            Impact factor:   5.279


  49 in total

1.  Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It.

Authors:  Tareisha L Dunlap; Shuai Wang; Charlotte Simmler; Shao-Nong Chen; Guido F Pauli; Birgit M Dietz; Judy L Bolton
Journal:  Chem Res Toxicol       Date:  2015-07-16       Impact factor: 3.739

2.  Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis.

Authors:  Ming Cheng; Liqin Ding; Hongfeng Kan; Hongmin Zhang; Benke Jiang; Yingjie Sun; Shijie Cao; Wei Li; Kazuo Koike; Feng Qiu
Journal:  J Nat Med       Date:  2019-06-19       Impact factor: 2.343

3.  Alleviative effect of licorice on copper chloride-induced oxidative stress in the brain: biochemical, histopathological, immunohistochemical, and genotoxic study.

Authors:  Heba El-Sayed Mostafa; Eman Ahmad Alaa-Eldin; Dalia Abdallah El-Shafei; Nehal S Abouhashem
Journal:  Environ Sci Pollut Res Int       Date:  2017-06-24       Impact factor: 4.223

4.  Antiproliferative and apoptotic potential of Glycyrrhizin against HPV16+ Caski cervical cancer cells: A plausible association with downreguation of HPV E6 and E7 oncogenes and Notch signaling pathway.

Authors:  Afza Ahmad; Rohit Kumar Tiwari; Prakriti Mishra; Ali G Alkhathami; Tahani M Almeleebia; Mohammad Y Alshahrani; Irfan Ahmad; Rawan Amer Asiri; Noura M Alabdullah; Mohamed Hussien; Mohd Saeed; Irfan Ahmad Ansari
Journal:  Saudi J Biol Sci       Date:  2022-01-31       Impact factor: 4.052

5.  Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

Authors:  Zeng-Yan Huang; Ling-Jun Wang; Jia-Jia Wang; Wen-Jun Feng; Zhong-Qi Yang; Shi-Hao Ni; Yu-Sheng Huang; Huan Li; Yi Yang; Ming-Qing Wang; Rong Hu; Heng Wan; Chan-Juan Wen; Shao-Xiang Xian; Lu Lu
Journal:  Br J Pharmacol       Date:  2018-12-04       Impact factor: 8.739

Review 6.  Botanicals and Their Bioactive Phytochemicals for Women's Health.

Authors:  Birgit M Dietz; Atieh Hajirahimkhan; Tareisha L Dunlap; Judy L Bolton
Journal:  Pharmacol Rev       Date:  2016-10       Impact factor: 25.468

7.  Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.

Authors:  Nittaya Boonmuen; Ping Gong; Zulfiqar Ali; Amar G Chittiboyina; Ikhlas Khan; Daniel R Doerge; William G Helferich; Kathryn E Carlson; Teresa Martin; Pawinee Piyachaturawat; John A Katzenellenbogen; Benita S Katzenellenbogen
Journal:  Steroids       Date:  2015-11-26       Impact factor: 2.668

8.  Deciphering the Formulation Secret Underlying Chinese Huo-Clearing Herbal Drink.

Authors:  Jianan Wang; Bo Zhou; Xiangdong Hu; Shuang Dong; Ming Hong; Jun Wang; Jian Chen; Jiuliang Zhang; Qiyun Zhang; Xiaohua Li; Alexander N Shikov; Sheng Hu; Xuebo Hu
Journal:  Front Pharmacol       Date:  2021-04-22       Impact factor: 5.810

9.  Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation.

Authors:  Shouyan Wu; Henglei Lu; Wenjie Wang; Luyao Song; Meng Liu; Yuhan Cao; Xinming Qi; Jianhua Sun; Likun Gong
Journal:  Cell Death Dis       Date:  2021-05-13       Impact factor: 9.685

10.  Dark Septate Endophytes Isolated From Wild Licorice Roots Grown in the Desert Regions of Northwest China Enhance the Growth of Host Plants Under Water Deficit Stress.

Authors:  Chao He; Wenquan Wang; Junling Hou; Xianen Li
Journal:  Front Microbiol       Date:  2021-06-23       Impact factor: 5.640

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