Stefania Carbone1, Rosabel Lobo Alvarez2, Annalisa Lamacchia3, Asuncion Almenar Gil4, Raquel Martin Hernandez5, Jose Luis Lopez Guerra1, Hugo Marsiglia6. 1. Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain. 2. Department of Radiation Oncology, Instituto Oncologico de Castilla La Mancha/Grupo IMO, Toledo, Spain. 3. Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain ; Department of Radiation Oncology, University of Bari, Bari, Italy. 4. Department of Radiology, Hospital Virgen de la Salud, Toledo, Spain. 5. Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain. 6. Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain ; Department of Radiation Oncology, Institut de cancérologie Gustave Roussy, Villejuif, Paris, France.
Abstract
BACKGROUND: Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated. AIM: Clinical outcome assessment of a patient with squamous cell carcinoma of the breast. MATERIALS AND METHODS: We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT). RESULTS: With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed. CONCLUSIONS: Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.
BACKGROUND: Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated. AIM: Clinical outcome assessment of a patient with squamous cell carcinoma of the breast. MATERIALS AND METHODS: We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT). RESULTS: With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed. CONCLUSIONS: Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.
Entities:
Keywords:
Breast cancer; Outcome; Squamous cell carcinoma
Authors: Bryan T Hennessy; Savitri Krishnamurthy; Sharon Giordano; Thomas A Buchholz; Shu W Kau; Zhigang Duan; Vicente Valero; Gabriel N Hortobagyi Journal: J Clin Oncol Date: 2005-11-01 Impact factor: 44.544
Authors: I Aparicio; A Martínez; G Hernández; D Hardisson; J De Santiago Journal: Eur J Obstet Gynecol Reprod Biol Date: 2007-05-03 Impact factor: 2.435