BACKGROUND: Whether the risk of cancer is increased in patients with chronic autoimmune thyroiditis is a controversial issue. METHODS: Between May 2005 and October 2012, 3777 fine-needle aspiration cytologies (FNACs) were performed on 2562 patients. Serum FT4, thyroid-stimulating hormone (TSH), anti-thyroglobulin antibody (TgAb), and anti-thyroperoxidase antibody (TPOAb) were determined. RESULTS: Patients with suspicious cytology were younger and presented smaller maximum lesion diameter. In patients with TgAb positivity, suspicious cytology was detected more frequently (9.4%) than patients without TgAb (5.7%; p = .04). No significant difference was recorded between benign and suspicious cytology in the positive TPOAb rate. Risk factors for suspicious cytology were younger age (odds ratio [OR], 0.94), smaller maximum diameter (0.95), single lesion (1.85), microcalcifications (3.45), and TgAb (1.74). Mixed solid/fluid content resulted as being a protective factor (0.34). According to multivariate logistic regression analysis, age, mixed content, and microcalcification confirmed significance. CONCLUSION: Thyroid nodule malignancy in patients with Hashimoto thyroiditis is not more frequent than in patients without thyroiditis.
BACKGROUND: Whether the risk of cancer is increased in patients with chronic autoimmune thyroiditis is a controversial issue. METHODS: Between May 2005 and October 2012, 3777 fine-needle aspiration cytologies (FNACs) were performed on 2562 patients. Serum FT4, thyroid-stimulating hormone (TSH), anti-thyroglobulin antibody (TgAb), and anti-thyroperoxidase antibody (TPOAb) were determined. RESULTS:Patients with suspicious cytology were younger and presented smaller maximum lesion diameter. In patients with TgAb positivity, suspicious cytology was detected more frequently (9.4%) than patients without TgAb (5.7%; p = .04). No significant difference was recorded between benign and suspicious cytology in the positive TPOAb rate. Risk factors for suspicious cytology were younger age (odds ratio [OR], 0.94), smaller maximum diameter (0.95), single lesion (1.85), microcalcifications (3.45), and TgAb (1.74). Mixed solid/fluid content resulted as being a protective factor (0.34). According to multivariate logistic regression analysis, age, mixed content, and microcalcification confirmed significance. CONCLUSION: Thyroid nodule malignancy in patients with Hashimoto thyroiditis is not more frequent than in patients without thyroiditis.
Authors: Nathalie Silva de Morais; Jessica Stuart; Haixia Guan; Zhihong Wang; Edmund S Cibas; Mary C Frates; Carol B Benson; Nancy L Cho; Mathew A Nehs; Caroline A Alexander; Ellen Marqusee; Mathew I Kim; Jochen H Lorch; Justine A Barletta; Trevor E Angell; Erik K Alexander Journal: J Endocr Soc Date: 2019-03-05
Authors: Maaike van Gerwen; Naomi Alpert; Wil Lieberman-Cribbin; Peter Cooke; Kimia Ziadkhanpour; Bian Liu; Eric Genden Journal: Int J Environ Res Public Health Date: 2020-01-22 Impact factor: 3.390