| Literature DB >> 24374337 |
Rui Hu1, Qiumei Du1, Xiangyun Yin1, Jingyun Li1, Tingting Wang2, Liguo Zhang3.
Abstract
Death receptor 6 (DR6) is a member of the death domain-containing receptors that belong to the TNFR superfamily. To date, the ligand for DR6 is still not clearly defined. Here, we developed a functional agonist monoclonal antibody (DQM3) against DR6, which bound to the first cysteine-rich domain. Importantly, DR6 signaling could be clearly activated by DQM3, which was dependent on its intracellular death domain. In addition, we demonstrated that the association between DR6 and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6-induced signaling activation. Taken together, our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody.Entities:
Keywords: Agonist antibody; CRD; DD; DR; DR6; Death domain; FADD; Fas-associated death domain; JNK; N-APP; N-terminal β-amyloid precursor protein; TNFR; TNFR-associated death domain protein; TRADD; TRAF; c-Jun N-terminal kinase; cysteine-rich domain; death domain; death receptor; siRNA; small interfering RNA; tumor necrosis factor receptor; tumor necrosis factor receptor-associated factor
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Year: 2013 PMID： 24374337 DOI： 10.1016/j.febslet.2013.12.010
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124