Literature DB >> 24374275

Truncated norzoanthamine exhibiting similar collagen protection activity, toward a promising anti-osteoporotic drug.

Hironori Inoue1, Daisuke Hidaka1, Seketsu Fukuzawa2, Kazuo Tachibana1.   

Abstract

The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. Due to its rarity and complicated structure, a practical supply method must be developed. Here, we designed a truncated norzoanthamine, which has two-thirds of the original structure, and found that it exhibited similar collagen protection activity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alkaloid; Collagen; Norzoanthamine; Osteoporosis

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Year:  2013        PMID: 24374275     DOI: 10.1016/j.bmcl.2013.12.032

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Enantioselective Synthesis of Caprolactam and Enone Precursors to the Heterocyclic DEFG Ring System of Zoanthenol.

Authors:  Jeffrey T Bagdanoff; Douglas C Behenna; Jennifer L Stockdill; Brian M Stoltz
Journal:  European J Org Chem       Date:  2016-04-19
  1 in total

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