Literature DB >> 24374273

Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.

Serena Fiorito1, Francesco Epifano2, Céline Bruyère3, Véronique Mathieu3, Robert Kiss3, Salvatore Genovese1.   

Abstract

A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 μM.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1,4-Naphthoquinones; Cancer; In vitro growth inhibition; Lapachol

Mesh：

Substances：

Year:  2013        PMID： 24374273     DOI： 10.1016/j.bmcl.2013.12.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

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Authors:  Eduardo H G da Cruz; Molly A Silvers; Guilherme A M Jardim; Jarbas M Resende; Bruno C Cavalcanti; Igor S Bomfim; Claudia Pessoa; Carlos A de Simone; Giancarlo V Botteselle; Antonio L Braga; Divya K Nair; Irishi N N Namboothiri; David A Boothman; Eufrânio N da Silva Júnior
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  9 in total

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