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Literature DB >> 24374271

Bifunctional thiosialosides inhibit influenza virus.

Yang Yang¹, Yun He¹, Xingzhe Li¹, Hieu Dinh¹, Suri S Iyer².

Abstract

We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).

Entities: Chemical Disease Species

Keywords: Bifunctional; Glycoconjugates; Influenza virus; Inhibitors; Sialic acid

Mesh：

Substances：

Year: 2013 PMID： 24374271 PMCID： PMC4397911 DOI： 10.1016/j.bmcl.2013.11.077

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

19 in total

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Authors: H Amano; H Uemoto; K Kuroda; Y Hosaka
Journal: J Gen Virol Date: 1992-08 Impact factor: 3.891

Review 2. The war against influenza: discovery and development of sialidase inhibitors.

Authors: Mark von Itzstein
Journal: Nat Rev Drug Discov Date: 2007-12 Impact factor: 84.694

3. Investigation of the stability of thiosialosides toward hydrolysis by sialidases using NMR spectroscopy.

Authors: J C Wilson; M J Kiefel; D I Angus; M von Itzstein
Journal: Org Lett Date: 1999-08-12 Impact factor: 6.005

4. Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009-2012.

Authors: Mai-Phuong Hoang Vu; Co Thach Nguyen; Le Khanh Hang Nguyen; Thi Kim Phuong Nguyen; Quynh Mai Le
Journal: Western Pac Surveill Response J Date: 2013-06-26

5. Rational design of potent sialidase-based inhibitors of influenza virus replication.

Authors: M von Itzstein; W Y Wu; G B Kok; M S Pegg; J C Dyason; B Jin; T Van Phan; M L Smythe; H F White; S W Oliver
Journal: Nature Date: 1993-06-03 Impact factor: 49.962

6. Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor.

Authors: Mitchell R White; Erika Crouch; Martin van Eijk; Max Hartshorn; Lily Pemberton; Ida Tornoe; Uffe Holmskov; Kevan L Hartshorn
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2004-12-17 Impact factor: 5.464

7. Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.

Authors: Simon J F Macdonald; Keith G Watson; Rachel Cameron; David K Chalmers; Derek A Demaine; Rob J Fenton; David Gower; J Nicole Hamblin; Stephanie Hamilton; Graham J Hart; Graham G A Inglis; Betty Jin; Haydn T Jones; Darryl B McConnell; Andy M Mason; Van Nguyen; Ian J Owens; Nigel Parry; Phillip A Reece; Stephen E Shanahan; Donna Smith; Wen-Yang Wu; Simon P Tucker
Journal: Antimicrob Agents Chemother Date: 2004-12 Impact factor: 5.191

8. Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.

Authors: Jun-Ichi Sakamoto; Tetsuo Koyama; Daisei Miyamoto; Sangchai Yingsakmongkon; Kazuya I P J Hidari; Wipawee Jampangern; Takashi Suzuki; Yasuo Suzuki; Yasuaki Esumi; Ken Hatano; Daiyo Terunuma; Koji Matsuoka
Journal: Bioorg Med Chem Lett Date: 2006-11-01 Impact factor: 2.823

Bifunctional thiosialosides inhibit influenza virus.

1. Immunoelectron microscopy of influenza A virus neuraminidase glycoprotein topography.

Review 2. The war against influenza: discovery and development of sialidase inhibitors.

3. Investigation of the stability of thiosialosides toward hydrolysis by sialidases using NMR spectroscopy.

4. Oseltamivir resistance among influenza viruses: surveillance in northern Viet Nam, 2009-2012.

5. Rational design of potent sialidase-based inhibitors of influenza virus replication.

6. Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor.

7. Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.

8. Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.

9. Detection of intact influenza viruses using biotinylated biantennary S-sialosides.

10. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.

1. Electrochemical assay to detect influenza viruses and measure drug susceptibility.

2. Highly specific and rapid glycan based amperometric detection of influenza viruses.

3. Glycan based detection and drug susceptibility of influenza virus.