Literature DB >> 2437423

Inhibitory effect of galanin on pancreatic polypeptide release by the perfused rat pancreas.

R A Silvestre, P Miralles, L Monge, M L Villanueva, J Marco.   

Abstract

We have investigated the effect of galanin infusion on unstimulated pancreatic polypeptide (PP) release as well as on the PP response to arginine by the perfused rat pancreas. Galanin significantly reduced unstimulated PP output. Addition of arginine to the perfusate evoked a biphasic pattern of PP release; the second phase of this PP response was delayed when galanin was simultaneously infused. These findings point to a regulatory role of galanin in the control of PP secretion.

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Year:  1987        PMID: 2437423     DOI: 10.1016/0024-3205(87)90094-4

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  3 in total

Review 1.  Galanin and the regulation of islet hormone secretion.

Authors:  B Ahrén; S Lindskog
Journal:  Int J Pancreatol       Date:  1992-06

2.  Tissue-specific expression of the rat galanin gene.

Authors:  L M Kaplan; E R Spindel; K J Isselbacher; W W Chin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

3.  Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary.

Authors:  L M Kaplan; S M Gabriel; J I Koenig; M E Sunday; E R Spindel; J B Martin; W W Chin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

  3 in total

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