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Literature DB >> 24374199

The endogenous substrates of brain CYP2D.

Xiaoshuang Wang¹, Jie Li², Guicheng Dong³, Jiang Yue⁴.

Abstract

CYP2D6, one of the major cytochrome P450 isoforms present in the human brain, is associated with the incidence and prevalence of central nervous system (CNS) diseases. Human CYP2D6 and rat CYP2D are involved in the metabolism of various neurotransmitters and neurosteroids. Brain CYP2D can be regulated by endogenous steroids, including sex hormones. The alteration of CYP2D-mediated metabolism induced by endogenous steroids may cause changes in sensitivity to environmental and industrial toxins and carcinogens as well as physiological and pathophysiological processes controlled by biologically active compounds. This review summarizes the current knowledge regarding the distribution, endogenous substrates, and regulation of brain CYP2D.

Entities: Chemical Disease Gene Species

Keywords: Brain; Cytochrome P450 2D; Endogenous substrates

Mesh：

Substances：

Year: 2013 PMID： 24374199 DOI： 10.1016/j.ejphar.2013.12.025

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

17 in total

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Review 7. A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.

Authors: Anutthaman Parthasarathy; Penelope J Cross; Renwick C J Dobson; Lily E Adams; Michael A Savka; André O Hudson
Journal: Front Mol Biosci Date: 2018-04-06