Literature DB >> 24373414

Clinical and ethical implications of mitochondrial gene transfer.

Shoukhrat Mitalipov1, Don P Wolf2.   

Abstract

Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in 5000-10,000 children and are associated with severe clinical symptoms. Novel reproductive techniques designed to replace mutated mtDNA in oocytes or early embryos have been proposed to prevent transmission of disease from parents to their children. Here we review the efficacy and safety of these approaches and their associated ethical and regulatory issues.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  assisted reproductive technologies; mtDNA mutations

Mesh：

Substances：

Year:  2014        PMID： 24373414      PMCID： PMC4005369          DOI： 10.1016/j.tem.2013.09.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  8 in total

1.  Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.

Authors:  D C Wallace; G Singh; M T Lott; J A Hodge; T G Schurr; A M Lezza; L J Elsas; E K Nikoskelainen
Journal:  Science       Date:  1988-12-09       Impact factor: 47.728

2.  Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.

Authors:  Akitsugu Sato; Tomohiro Kono; Kazuto Nakada; Kaori Ishikawa; Shin-Ichi Inoue; Hiromichi Yonekawa; Jun-Ichi Hayashi
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-07       Impact factor: 11.205

3.  Nuclear transplantation in the mouse embryo by microsurgery and cell fusion.

Authors:  J McGrath; D Solter
Journal:  Science       Date:  1983-06-17       Impact factor: 47.728

4.  Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.

Authors:  Daniel Paull; Valentina Emmanuele; Keren A Weiss; Nathan Treff; Latoya Stewart; Haiqing Hua; Matthew Zimmer; David J Kahler; Robin S Goland; Scott A Noggle; Robert Prosser; Michio Hirano; Mark V Sauer; Dieter Egli
Journal:  Nature       Date:  2012-12-19       Impact factor: 49.962

5.  Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease.

Authors:  Lyndsey Craven; Helen A Tuppen; Gareth D Greggains; Stephen J Harbottle; Julie L Murphy; Lynsey M Cree; Alison P Murdoch; Patrick F Chinnery; Robert W Taylor; Robert N Lightowlers; Mary Herbert; Douglass M Turnbull
Journal:  Nature       Date:  2010-04-14       Impact factor: 49.962

6.  Pathogenic mitochondrial DNA mutations are common in the general population.

Authors:  Hannah R Elliott; David C Samuels; James A Eden; Caroline L Relton; Patrick F Chinnery
Journal:  Am J Hum Genet       Date:  2008-08       Impact factor: 11.025

7.  Mitochondrial gene replacement in primate offspring and embryonic stem cells.

Authors:  Masahito Tachibana; Michelle Sparman; Hathaitip Sritanaudomchai; Hong Ma; Lisa Clepper; Joy Woodward; Ying Li; Cathy Ramsey; Olena Kolotushkina; Shoukhrat Mitalipov
Journal:  Nature       Date:  2009-08-26       Impact factor: 49.962

8.  Towards germline gene therapy of inherited mitochondrial diseases.

Authors:  Masahito Tachibana; Paula Amato; Michelle Sparman; Joy Woodward; Dario Melguizo Sanchis; Hong Ma; Nuria Marti Gutierrez; Rebecca Tippner-Hedges; Eunju Kang; Hyo-Sang Lee; Cathy Ramsey; Keith Masterson; David Battaglia; David Lee; Diana Wu; Jeffrey Jensen; Phillip Patton; Sumita Gokhale; Richard Stouffer; Shoukhrat Mitalipov
Journal:  Nature       Date:  2012-10-24       Impact factor: 49.962
  8 in total
  13 in total

1.  Is the World of ART Ready for a Ménage à Trois?

Authors:  Gautam N Allahbadia
Journal:  J Obstet Gynaecol India       Date:  2015-04

Review 2.  Mitochondrial Epigenetics and Environmental Exposure.

Authors:  Luca Lambertini; Hyang-Min Byun
Journal:  Curr Environ Health Rep       Date:  2016-09

Review 3.  Maternal control of early embryogenesis in mammals.

Authors:  Kun Zhang; George W Smith
Journal:  Reprod Fertil Dev       Date:  2015-07       Impact factor: 2.311

Review 4.  CRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations.

Authors:  Sarah Fogleman; Casey Santana; Casey Bishop; Alyssa Miller; David G Capco
Journal:  Am J Stem Cells       Date:  2016-08-20

Review 5.  Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases.

Authors:  Li Yue; Hongwei Yao
Journal:  Br J Pharmacol       Date:  2016-06-21       Impact factor: 8.739

6.  Mutation-specific effects in germline transmission of pathogenic mtDNA variants.

Authors:  Auke B C Otten; Suzanne C E H Sallevelt; Phillippa J Carling; Joseph C F M Dreesen; Marion Drüsedau; Sabine Spierts; Aimee D C Paulussen; Christine E M de Die-Smulders; Mary Herbert; Patrick F Chinnery; David C Samuels; Patrick Lindsey; Hubert J M Smeets
Journal:  Hum Reprod       Date:  2018-07-01       Impact factor: 6.918

Review 7.  The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.

Authors:  Heide Schatten; Qing-Yuan Sun; Randall Prather
Journal:  Reprod Biol Endocrinol       Date:  2014-11-24       Impact factor: 5.211

8.  Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA.

Authors:  Ananta Paine; Manoj Kumar Jaiswal
Journal:  Front Cell Neurosci       Date:  2016-09-23       Impact factor: 5.505

Review 9.  Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage.

Authors:  Bettina P Mihalas; Kate A Redgrove; Eileen A McLaughlin; Brett Nixon
Journal:  Oxid Med Cell Longev       Date:  2017-10-18       Impact factor: 6.543

Review 10.  Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment.

Authors:  Filippo Maria Ubaldi; Danilo Cimadomo; Alberto Vaiarelli; Gemma Fabozzi; Roberta Venturella; Roberta Maggiulli; Rossella Mazzilli; Susanna Ferrero; Antonio Palagiano; Laura Rienzi
Journal:  Front Endocrinol (Lausanne)       Date:  2019-02-20       Impact factor: 5.555
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.