Literature DB >> 24372513

Small molecules for cell reprogramming and heart repair: progress and perspective.

Min Xie1, Nan Cao, Sheng Ding.   

Abstract

Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical approaches for producing ample supplies of cells, such as pluripotent stem cells and cardiomyocytes, hold promise as practical means to achieve safe, facile cell-based therapy for cardiac repair and regenerative medicine. In this review, we describe recent advances in the application of small molecules to improve the generation and maintenance of pluripotent stem cells. We also describe new directions in heart repair and regeneration in which chemical approaches may find their application.

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Year:  2014        PMID： 24372513      PMCID： PMC3951179          DOI： 10.1021/cb400865w

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  107 in total

1.  Feeder-independent culture of human embryonic stem cells.

Authors:  Tenneille E Ludwig; Veit Bergendahl; Mark E Levenstein; Junying Yu; Mitchell D Probasco; James A Thomson
Journal:  Nat Methods       Date:  2006-08       Impact factor: 28.547

2.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors:  Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

Review 3.  Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

Authors:  So Gun Hong; Cynthia E Dunbar; Thomas Winkler
Journal:  Mol Ther       Date:  2012-12-04       Impact factor: 11.454

4.  Adenoviral human BCL-2 transgene expression attenuates early donor cell death after cardiomyoblast transplantation into ischemic rat hearts.

Authors:  Ingo Kutschka; Theo Kofidis; Ian Y Chen; Georges von Degenfeld; Monika Zwierzchoniewska; Grant Hoyt; Takayasu Arai; Darren R Lebl; Stephen L Hendry; Ahmad Y Sheikh; David T Cooke; Andrew Connolly; Helen M Blau; Sanjiv S Gambhir; Robert C Robbins
Journal:  Circulation       Date:  2006-07-04       Impact factor: 29.690

5.  Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

Authors:  Steven J Kattman; Alec D Witty; Mark Gagliardi; Nicole C Dubois; Maryam Niapour; Akitsu Hotta; James Ellis; Gordon Keller
Journal:  Cell Stem Cell       Date:  2011-02-04       Impact factor: 24.633

6.  Targeting native adult heart progenitors with cardiogenic small molecules.

Authors:  Jamie L Russell; Sean C Goetsch; Hector R Aguilar; Doug E Frantz; Jay W Schneider
Journal:  ACS Chem Biol       Date:  2012-04-13       Impact factor: 5.100

7.  Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.

Authors:  Paul W Burridge; Gordon Keller; Joseph D Gold; Joseph C Wu
Journal:  Cell Stem Cell       Date:  2012-01-06       Impact factor: 24.633

8.  Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions.

Authors:  Jeanette Beers; Daniel R Gulbranson; Nicole George; Lauren I Siniscalchi; Jeffrey Jones; James A Thomson; Guokai Chen
Journal:  Nat Protoc       Date:  2012-10-25       Impact factor: 13.491

Review 9.  Strategies and new developments in the generation of patient-specific pluripotent stem cells.

Authors:  Shinya Yamanaka
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

10.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.

Authors:  Masato Nakagawa; Michiyo Koyanagi; Koji Tanabe; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Keisuke Okita; Yuji Mochiduki; Nanako Takizawa; Shinya Yamanaka
Journal:  Nat Biotechnol       Date:  2007-11-30       Impact factor: 54.908
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  6 in total

Review 1.  Generation of pluripotent stem cells without the use of genetic material.

Authors:  Akon Higuchi; Qing-Dong Ling; S Suresh Kumar; Murugan A Munusamy; Abdullah A Alarfaj; Yung Chang; Shih-Hsuan Kao; Ke-Chen Lin; Han-Chow Wang; Akihiro Umezawa
Journal:  Lab Invest       Date:  2014-11-03       Impact factor: 5.662

2.  Making cardiomyocytes with your chemistry set: Small molecule-induced cardiogenesis in somatic cells.

Authors:  Woong-Hee Kim; Da-Woon Jung; Darren Reece Williams
Journal:  World J Cardiol       Date:  2015-03-26

Review 3.  Therapeutical Strategies for Spinal Cord Injury and a Promising Autologous Astrocyte-Based Therapy Using Efficient Reprogramming Techniques.

Authors:  Hao Yang; Cui-Cui Liu; Chun-Yu Wang; Qian Zhang; Jiang An; Lingling Zhang; Ding-Jun Hao
Journal:  Mol Neurobiol       Date:  2015-04-12       Impact factor: 5.590

Review 4.  Translational aspects of cardiac cell therapy.

Authors:  Cheng-Han Chen; Konstantina-Ioanna Sereti; Benjamin M Wu; Reza Ardehali
Journal:  J Cell Mol Med       Date:  2015-06-27       Impact factor: 5.310

5.  Small molecules for cell reprogramming: a systems biology analysis.

Authors:  Anna Knyazer; Gabriela Bunu; Dmitri Toren; Teodora Bucaciuc Mracica; Yael Segev; Marina Wolfson; Khachik K Muradian; Robi Tacutu; Vadim E Fraifeld
Journal:  Aging (Albany NY)       Date:  2021-12-17       Impact factor: 5.682

6.  Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

Authors:  Sini M Kinnunen; Marja Tölli; Mika J Välimäki; Erhe Gao; Zoltan Szabo; Jaana Rysä; Mónica P A Ferreira; Pauli Ohukainen; Raisa Serpi; Alexandra Correia; Ermei Mäkilä; Jarno Salonen; Jouni Hirvonen; Hélder A Santos; Heikki Ruskoaho
Journal:  Sci Rep       Date:  2018-03-15       Impact factor: 4.379
  6 in total

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