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Literature DB >> 24371773

Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.

Richard Lemal¹, Carine Chaleteix¹, Patrice Minard², Corinne Roche³, Jacques-Olivier Bay¹, Olivier Tournilhac¹, Thierry Lamy⁴.

Abstract

Large granular lymphocytic (LGL) leukemia is an uncommon clonal lymphoproliferative disorder. Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular autoimmune disease caused by pathogenic autoantibodies targeting the voltage-gated calcium channels (VGCC) on the presynaptic nerve terminal. We here describe the case of a 77-year old patient with LGL leukemia, associated with a seropositive and symptomatic LEMS and a seronegative rheumatoid arthritis. LGL leukemia treatment clearly improved LEMS symptoms, and led to anti-VGCC antibodies value decrease. To our knowledge, this is the first ever described association between LGL leukemia and LEMS.

Entities: Disease Species

Keywords: LGL leukemia; Lambert–Eaton Myasthenic Syndrome; Large granular lymphocytic leukemia

Year: 2013 PMID： 24371773 PMCID： PMC3850575 DOI： 10.1016/j.lrr.2013.02.004

Source DB: PubMed Journal: Leuk Res Rep ISSN： 2213-0489

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References

12 in total

Large granular lymphocytic leukemia associated with Lambert-Eaton Myasthenic Syndrome: A case report.

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Review 7. The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders.

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