Literature DB >> 24371588

Abnormally low hCG in a complete hydatidiform molar pregnancy: The hook effect.

James L Nodler1, Kenneth H Kim2, Ronald D Alvarez2.   

Abstract

► The hook effect occurs with extremely high levels of hCG, saturating detection antibodies, leading to falsely low laboratory results. ► In the literature, descriptions of the hook effect are rare in cases of gestational trophoblastic diseases. ► If unrecognized, this can lead to delayed therapy or mismanagement of care.

Entities:  

Keywords:  Falsely low hCG; Hook effect; Molar pregnancy

Year:  2011        PMID： 24371588      PMCID： PMC3857678          DOI： 10.1016/j.gynor.2011.10.003

Source DB:  PubMed          Journal:  Gynecol Oncol Case Rep        ISSN： 2211-338X


  4 in total

Review 1.  Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites.

Authors:  L A Cole
Journal:  Clin Chem       Date:  1997-12       Impact factor: 8.327

2.  Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free beta subunit and the beta core fragment in quantitative hCG assays.

Authors:  David G Grenache; Dina N Greene; Anand S Dighe; Corinne R Fantz; Daniel Hoefner; Christopher McCudden; Lori Sokoll; Carmen L Wiley; Ann M Gronowski
Journal:  Clin Chem       Date:  2010-10-07       Impact factor: 8.327

Review 3.  Current management of gestational trophoblastic diseases.

Authors:  Ross S Berkowitz; Donald P Goldstein
Journal:  Gynecol Oncol       Date:  2008-10-12       Impact factor: 5.482

4.  The quagmire of hCG and hCG testing in gynecologic oncology.

Authors:  Carolyn Y Muller; Laurence A Cole
Journal:  Gynecol Oncol       Date:  2008-11-12       Impact factor: 5.482
  4 in total
  1 in total

1.  A twin pregnancy with a hydatidiform mole and a coexisting live fetus: prenatal diagnosis, treatment, and follow-up.

Authors:  Antonio Braga; Bruna Obeica; Heron Werner; Sue Yazaki Sun; Joffre Amim Júnior; Jorge Rezende Filho; Edward Araujo Júnior
Journal:  J Ultrason       Date:  2017-12-29
  1 in total

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