| Literature DB >> 24371575 |
Naveen Sathyan1, Rosamma Philip1, E R Chaithanya1, P R Anil Kumar1, Swapna P Antony1.
Abstract
Histone H2A participates in host defense responses by producing antimicrobial peptides (AMPs). The present study deals with identification of a putative antimicrobial sequence, Himanturin from the histone H2A of Round Whip Ray, Himantura pastinacoides. A 204 bp fragment encoding 68 amino acid residues was amplified from cDNA of Round Whip Ray, H. pastinacoides. Himanturin exhibited high similarity to previously reported histone H2A derived AMPs indicating the presence of an antimicrobial sequence motif. Physicochemical properties of Himanturin suggest it to be a potential antimicrobial candidate.Entities:
Keywords: Antimicrobial peptide; Elasmobranch; Himantura pastinacoides; Himanturin; Histone H2A
Year: 2012 PMID: 24371575 PMCID: PMC3862380 DOI: 10.1016/j.rinim.2012.06.001
Source DB: PubMed Journal: Results Immunol ISSN: 2211-2839